新生儿甲状腺毒症

Neonatal Thyrotoxicosis.

作者信息

Samuels Stephanie L, Namoc Sisi M, Bauer Andrew J

机构信息

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.

National Institute of Child Health, 600 Brasil Avenue, Breña - Lima 05, Peru.

出版信息

Clin Perinatol. 2018 Mar;45(1):31-40. doi: 10.1016/j.clp.2017.10.001. Epub 2017 Dec 16.

DOI:10.1016/j.clp.2017.10.001

PMID:29406005

Abstract

Neonatal thyrotoxicosis (hyperthyroidism) is less prevalent than congenital hypothyroidism; however, it can lead to significant morbidity and mortality if not promptly recognized and adequately treated. Most cases are transient, secondary to maternal autoimmune hyperthyroidism (Graves disease [GD]). This article summarizes recommendations for screening and management of hyperthyroidism in both the fetal and neonatal periods, with a focus on neonatal thyrotoxicosis secondary to maternal GD. Early monitoring and treatment are crucial for optimizing short-term and long-term patient outcomes.

摘要

新生儿甲状腺毒症（甲亢）不如先天性甲状腺功能减退症常见；然而，如果不能及时识别并得到充分治疗，它可能导致严重的发病和死亡。大多数病例是短暂的，继发于母体自身免疫性甲亢（格雷夫斯病[GD]）。本文总结了胎儿期和新生儿期甲亢筛查和管理的建议，重点是继发于母体GD的新生儿甲状腺毒症。早期监测和治疗对于优化患者的短期和长期预后至关重要。