Department of Microbiology, Faculty of Science, Mahidol University, 272, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
Pornchai Matangkasombut Center for Microbial Genomics, Department of Microbiology, Faculty of Science, Mahidol University, 272, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
Sci Rep. 2022 Mar 9;12(1):4185. doi: 10.1038/s41598-022-08097-0.
Streptococcus agalactiae, also known as Lancefield Group B Streptococcus (GBS), is typically regarded as a neonatal pathogen; however, several studies have shown that the bacteria are capable of causing invasive diseases in non-pregnant adults as well. The majority of documented cases were from Southeast Asian countries, and the most common genotype found was ST283, which is also known to be able to infect fish. This study sequenced 12 GBS ST283 samples collected from adult patients in Thailand. Together with publicly available sequences, we performed temporo-spatial analysis and estimated population dynamics of the bacteria. Putative drug resistance genes were also identified and characterized, and the drug resistance phenotypes were validated experimentally. The results, together with historical records, draw a detailed picture of the past transmission history of GBS ST283 in Southeast Asia.
无乳链球菌，又称 B 群链球菌（GBS），通常被认为是一种新生儿病原体；然而，有几项研究表明，该细菌也能够引起非孕妇成年人的侵袭性疾病。已记录的大多数病例来自东南亚国家，发现的最常见基因型是 ST283，这种基因型也已知能够感染鱼类。本研究对从泰国成年患者中收集的 12 个无乳链球菌 ST283 样本进行了测序。我们结合公开的序列，进行了时空分析，并估计了细菌的种群动态。还鉴定和表征了推测的耐药基因，并通过实验验证了耐药表型。这些结果，结合历史记录，详细描绘了东南亚无乳链球菌 ST283 的过去传播史。
