Dieberg G, Sartin J L, Kemppainen R J, Oliver E H
Res Vet Sci. 1986 May;40(3):347-51.
Insulin binding characteristics of canine erythrocyte insulin receptors were studied before and after a 72-hour fast, and one and three days following glucocorticoid (dexamethasone) administration. The 72-hour fast tended to increase maximum insulin binding, but no significant differences were found. The administration of dexamethasone resulted in an increased maximum binding of insulin to its receptors which, at day 1, was due to an increase in receptor concentration, and at day 3, to an increased insulin binding affinity of the receptor. These data suggest that the erythrocyte insulin receptor may be useful in clinical and experimental studies in the dog.
研究了犬红细胞胰岛素受体在禁食72小时前后以及给予糖皮质激素（地塞米松）后1天和3天的胰岛素结合特性。72小时禁食倾向于增加最大胰岛素结合量，但未发现显著差异。地塞米松的给药导致胰岛素与其受体的最大结合量增加，在第1天，这是由于受体浓度增加，而在第3天，是由于受体的胰岛素结合亲和力增加。这些数据表明，红细胞胰岛素受体可能在犬的临床和实验研究中有用。
