Zhang S W, Li H, Zhang E Q
Third Department of Internal Medicine, No. 202 Hospital of PLA, Shenyang.
Zhonghua Nei Ke Za Zhi. 1994 Oct;33(10):681-3.
It is shown that the maximum specific binding rate (B/T) of erythrocyte membrane receptor to insulin was significantly decreased, the concentration of plasma insulin was significantly increased and the level of plasma glucose was not obviously changed after taking hydrocortisone (1.25mg/kg) or dexamethasone (37.5 micrograms/kg) orally. Scatchard analysis showed that decreased B/T was not mainly due to the change of the affinity or number of foci of insulin receptors, as no significant influence on insulin binding was found in vitro. The data suggested that the effect of both drugs on insulin receptor was multifactorial, including the secretion of insulin as well as the combination of insulin to its receptors.
结果表明，口服氢化可的松（1.25mg/kg）或地塞米松（37.5微克/千克）后，红细胞膜受体与胰岛素的最大特异性结合率（B/T）显著降低，血浆胰岛素浓度显著升高，血浆葡萄糖水平无明显变化。Scatchard分析表明，B/T降低并非主要由于胰岛素受体亲和力或结合位点数量的改变，因为在体外未发现对胰岛素结合有显著影响。数据提示，两种药物对胰岛素受体的作用是多因素的，包括胰岛素的分泌以及胰岛素与其受体的结合。
