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细菌耐药性的临床视角

Clinical Perspective of Antimicrobial Resistance in Bacteria.

作者信息

Zhu Ying, Huang Wei E, Yang Qiwen

机构信息

Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

出版信息

Infect Drug Resist. 2022 Mar 2;15:735-746. doi: 10.2147/IDR.S345574. eCollection 2022.

DOI:10.2147/IDR.S345574
PMID:35264857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8899096/
Abstract

Antimicrobial resistance (AMR) has become a global clinical problem in recent years. With the discovery of antibiotics, infections were not a deadly problem for clinicians as they used to be. However, worldwide AMR comes with the overuse/misuse of antibiotics and the spread of resistance is deteriorated by a multitude of mobile genetic elements and relevant resistant genes. This review provides an overview of the current situation, mechanism, epidemiology, detection methods and clinical treatment for antimicrobial resistant genes in clinical important bacteria including methicillin-resistant (MRSA), vancomycin-resistant (VRE), penicillin-resistant (PRSP), extended-spectrum β-lactamase-producing , acquired AmpC β-lactamase-producing , carbapenemase-producing (CPE), multidrug-resistant (MDR) and

摘要

近年来，抗菌药物耐药性（AMR）已成为一个全球性的临床问题。随着抗生素的发现，感染对临床医生来说不再像过去那样是致命问题。然而，全球范围内的抗菌药物耐药性与抗生素的过度使用/滥用相关，并且多种移动遗传元件和相关耐药基因加剧了耐药性的传播。本综述概述了临床重要细菌中抗菌耐药基因的现状、机制、流行病学、检测方法和临床治疗，这些细菌包括耐甲氧西林金黄色葡萄球菌（MRSA）、耐万古霉素肠球菌（VRE）、耐青霉素肺炎链球菌（PRSP）、产超广谱β-内酰胺酶细菌、产获得性AmpCβ-内酰胺酶细菌、产碳青霉烯酶细菌（CPE）、多重耐药菌（MDR）等。

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