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黄花棒多糖通过调节小鼠氧化应激、炎症和肠道微生物群减轻AOM/DSS诱导的结肠癌发生

Albuca Bracteata Polysaccharides Attenuate AOM/DSS Induced Colon Tumorigenesis via Regulating Oxidative Stress, Inflammation and Gut Microbiota in Mice.

作者信息

Qin Ziyan, Yuan Xinyu, Liu Jian, Shi Zhuqing, Cao Leipeng, Yang Lexuan, Wu Kai, Lou Yongliang, Tong Haibin, Jiang Lei, Du Jimei

机构信息

Department of Microbiology and Immunology, School of Laboratory Medicine, Wenzhou Medical University, Wenzhou Key Laboratory of Sanitary Microbiology, Wenzhou, China.

College of Life and Environmental Science, Wenzhou University, Wenzhou, China.

出版信息

Front Pharmacol. 2022 Feb 21;13:833077. doi: 10.3389/fphar.2022.833077. eCollection 2022.

DOI:10.3389/fphar.2022.833077
PMID:35264966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8899018/
Abstract

Inflammation is an important risk factor in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Accumulating evidence indicates that some phytochemicals have anti-cancer properties. Polysaccharides extracted from Albuca bracteata (AB) have been reported to possess anti-neoplastic activities on colorectal cancer (CRC) models. However, it is still unclear whether they exert therapeutic effects on colorectal cancer. In this study, we investigate the properties of polysaccharides of A. bracteate, named ABP. The average molecular weight of ABP was 18.3 kDa and ABP consisted of glucose, mannose, galactose, xylose, galacturonic acid, glucuronic acid at a molar ratio of 37.8:8:2.5:1.7:1:1. An Azoxymethane/Dextran sodium sulfate (AOM/DSS) induced CAC mouse model was established. The CAC mice treated with ABP showed smaller tumor size and lower tumor incidence than untreated ones. ABP increased anti-inflammatory cytokine IL-10, inhibited secretion of pro-inflammatory cytokines (IL-6, IFN-γ, and TNF-α), mitigated oxidative stress by increasing GSH and decreasing MDA levels, suppressed the activation of STAT3 and expressions of its related genes c-Myc and cyclin D1. Moreover, ABP treatment increased the relative abundance of beneficial bacteria (Ruminococcaceae, and ) and the levels of fecal short-chain fatty acid (SCFA) in CAC model mice. In summary, our data suggest that ABP could be a potential therapeutic agent for treating CAC.

摘要

炎症是炎症性肠病（IBD）和结肠炎相关结直肠癌（CAC）发生发展的重要危险因素。越来越多的证据表明，一些植物化学物质具有抗癌特性。据报道，从镰叶吊兰（AB）中提取的多糖对结直肠癌（CRC）模型具有抗肿瘤活性。然而，它们是否对结直肠癌具有治疗作用仍不清楚。在本研究中，我们研究了镰叶吊兰多糖（命名为ABP）的特性。ABP的平均分子量为18.3 kDa，由葡萄糖、甘露糖、半乳糖、木糖、半乳糖醛酸、葡萄糖醛酸以37.8:8:2.5:1.7:1:1的摩尔比组成。建立了氧化偶氮甲烷/葡聚糖硫酸钠（AOM/DSS）诱导的CAC小鼠模型。与未治疗的CAC小鼠相比，接受ABP治疗的小鼠肿瘤体积更小，肿瘤发生率更低。ABP增加抗炎细胞因子IL-10，抑制促炎细胞因子（IL-6、IFN-γ和TNF-α）的分泌，通过增加GSH和降低MDA水平减轻氧化应激，抑制STAT3的激活及其相关基因c-Myc和细胞周期蛋白D1的表达。此外，ABP治疗增加了CAC模型小鼠中有益细菌（瘤胃球菌科等）的相对丰度和粪便短链脂肪酸（SCFA）水平。总之，我们的数据表明ABP可能是治疗CAC的潜在治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/f585ce388ed4/fphar-13-833077-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/703e862f6e20/fphar-13-833077-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/e347328f4369/fphar-13-833077-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/a6e31e0109db/fphar-13-833077-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/fde45eddae48/fphar-13-833077-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/781bb80b94d9/fphar-13-833077-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/e19bd4ec3464/fphar-13-833077-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/7fae1afb5571/fphar-13-833077-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/e94fd90c86d6/fphar-13-833077-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/f585ce388ed4/fphar-13-833077-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/703e862f6e20/fphar-13-833077-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/e347328f4369/fphar-13-833077-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/a6e31e0109db/fphar-13-833077-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/fde45eddae48/fphar-13-833077-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/781bb80b94d9/fphar-13-833077-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/e19bd4ec3464/fphar-13-833077-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/7fae1afb5571/fphar-13-833077-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/e94fd90c86d6/fphar-13-833077-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8899018/f585ce388ed4/fphar-13-833077-g009.jpg

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[5]
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[6]
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[7]
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[8]
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[9]
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本文引用的文献

[1]
Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder.

Gut. 2022-8

[2]
Polysaccharides Synergistically Enhance the Anti-Tumor Efficacy of 5-Fluorouracil Against Colorectal Cancer by Modulating β-Catenin Signaling and Intestinal Flora.

Front Pharmacol. 2021-9-3

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Nutrients. 2021-8-22

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Mol Oncol. 2021-12

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Cells. 2021-5-17

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BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism.

Cell Death Dis. 2021-2-10

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Appl Biochem Biotechnol. 2021-6

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