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通过调节 -防御素预防大鼠牙周炎。

Prevents Periodontitis Induced by in Rats by Regulating -Defensins.

机构信息

Department of Stomatology, Shanghai Xuhui District Dental Center, 500 Fenglin Road, Shanghai 200032, China.

Department of Stomatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 201203, China.

出版信息

Comput Math Methods Med. 2022 Feb 27;2022:4968016. doi: 10.1155/2022/4968016. eCollection 2022.

DOI:10.1155/2022/4968016
PMID:35265172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8898852/
Abstract

OBJECTIVE

To study the preventive effect of () on periodontitis induced by () in rats.

METHODS

Eighteen 8-week-old female rats were randomly divided into three groups: Sham group, Trehalose group, and SBT2171 (LH2171) group. We measured the distance of the cementoenamel junction-alveolar bone crest (CEJ-ABC) to evaluate alveolar bone resorption. Hematoxylin-eosin staining was used to observe the histopathological changes of rat hemimaxillary tissues. We detected the expression of -defensins, tumor necrosis factor- (TNF-), interleukin- (IL-) 1, and IL-6 and the number of in rat gingival tissues by quantitative reverse transcriptase polymerase chain reaction. The levels of IL-1, IL-6, and TNF- in rat gingival tissues were also measured by enzyme-linked immunosorbent assay.

RESULTS

Compared with the Trehalose group, the distance of CEJ-ABC was prominently reduced and alveolar bone resorption was notably improved in the LH2171 group. And the infiltration of inflammatory cells in the hemimaxillary tissue decreased obviously, periodontal fibers were arranged neatly, connective tissue small blood vessels proliferated, and the number of reduced significantly in the LH2171 group. In addition, the mRNA expression and release of inflammatory factors in the gingival tissues in the LH2171 group were notably lower than those in the Trehalose group. On the 21st and 36th day, the expression of -defensins in the gingival tissue of the LH2171 group increased significantly.

CONCLUSION

improves alveolar bone resorption and increases the expression of -defensins thereby inhibiting the number of and thus prevents periodontitis.

摘要

目的

研究（）对（）诱导的大鼠牙周炎的预防作用。

方法

将 18 只 8 周龄雌性大鼠随机分为三组：假手术组、海藻糖组和 SBT2171（LH2171）组。我们测量牙釉质牙骨质界-牙槽骨嵴（CEJ-ABC）的距离，以评估牙槽骨吸收。苏木精-伊红染色观察大鼠颌组织的组织病理学变化。通过定量逆转录聚合酶链反应检测大鼠牙龈组织中 -防御素、肿瘤坏死因子-（TNF-）、白细胞介素-（IL-）1 和 IL-6 的表达和 数量。通过酶联免疫吸附试验测定大鼠牙龈组织中 IL-1、IL-6 和 TNF-的水平。

结果

与海藻糖组相比，LH2171 组 CEJ-ABC 的距离明显缩短，牙槽骨吸收明显改善。颌组织中炎症细胞浸润明显减少，牙周纤维排列整齐，结缔组织小血管增生，LH2171 组 数量明显减少。此外，LH2171 组牙龈组织中炎症因子的 mRNA 表达和释放明显低于海藻糖组。在第 21 天和第 36 天，LH2171 组牙龈组织中 -防御素的表达明显增加。

结论

LH2171 可改善牙槽骨吸收，增加 -防御素的表达，从而抑制 数量，进而预防牙周炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/ba8b8d94b99a/CMMM2022-4968016.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/53e12b662910/CMMM2022-4968016.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/d87a5b427e8d/CMMM2022-4968016.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/e9266595fe06/CMMM2022-4968016.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/b3107479a9a0/CMMM2022-4968016.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/ba8b8d94b99a/CMMM2022-4968016.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/53e12b662910/CMMM2022-4968016.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/d87a5b427e8d/CMMM2022-4968016.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/e9266595fe06/CMMM2022-4968016.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/b3107479a9a0/CMMM2022-4968016.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9807/8898852/ba8b8d94b99a/CMMM2022-4968016.005.jpg

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