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NOX4 表达在癌症患者中的预后价值：系统评价和荟萃分析。

Prognostic Value of NOX4 Expression in Cancer Patients: A Systematic Review and Meta-analysis.

机构信息

Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.

Department of Pathology, Jeju National University School of Medicine, Jeju, Republic of Korea.

出版信息

Dis Markers. 2022 Feb 28;2022:8567642. doi: 10.1155/2022/8567642. eCollection 2022.

DOI:10.1155/2022/8567642
PMID:35265227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8901360/
Abstract

BACKGROUND

Recent studies have shown that nicotinamide adenosine dinucleotide phosphate oxidase 4 (NOX4) is related to cancer development, proliferation, invasion, epithelial-to-mesenchymal transition, and metastasis. The prognostic value of NOX4 expression although has been reported in various cancers, it remains unclear as several studies have reported conflicting results. Therefore, the purpose of this study was to systematically investigate the prognostic value of NOX4 expression in cancer patients.

METHOD

Appropriate studies were collected by searching the PubMed, EMBASE, and Cochrane library databases, and the prognostic value of NOX4 expression in cancer patients was assessed through a meta-analysis.

RESULTS

Nine eligible studies involving 2675 cancer patients were included in this meta-analysis. We found that NOX4 expression is related to prognosis in cancer patients. In particular, high expression of NOX4 was significantly associated with overall survival in patients with gastrointestinal cancer (hazard ratio [HR]: 1.83, 95% confidence interval [CI]: 1.39-2.42, < 0.001).

CONCLUSION

NOX4 expression is significantly correlated with overall survival in patients with gastrointestinal cancer, indicating that it could be a potential prognostic marker.

摘要

背景

最近的研究表明，烟酰胺腺嘌呤二核苷酸磷酸氧化酶 4（NOX4）与癌症的发生、增殖、侵袭、上皮间质转化和转移有关。虽然已经有研究报道了 NOX4 表达的预后价值，但由于一些研究结果相互矛盾，其预后价值仍不清楚。因此，本研究旨在系统地研究 NOX4 表达在癌症患者中的预后价值。

方法

通过检索 PubMed、EMBASE 和 Cochrane 图书馆数据库收集合适的研究，并通过荟萃分析评估 NOX4 表达在癌症患者中的预后价值。

结果

本荟萃分析纳入了 9 项符合条件的研究，共 2675 例癌症患者。结果表明，NOX4 表达与癌症患者的预后相关。特别是，NOX4 高表达与胃肠道癌患者的总生存率显著相关（风险比[HR]：1.83，95%置信区间[CI]：1.39-2.42，<0.001）。

结论

NOX4 表达与胃肠道癌患者的总生存率显著相关，表明其可能是一种潜在的预后标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/ba6799b2d0bb/DM2022-8567642.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/47a21b26d493/DM2022-8567642.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/ba6799b2d0bb/DM2022-8567642.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/47a21b26d493/DM2022-8567642.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/d30ce132fb09/DM2022-8567642.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/0925b778a18f/DM2022-8567642.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/34e33062fcf3/DM2022-8567642.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/12162eaea80b/DM2022-8567642.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/ae94aacc89d5/DM2022-8567642.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/8901360/ba6799b2d0bb/DM2022-8567642.007.jpg

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