Mun Sujeong, Park Kihyun, Lee Siwoo
KM Data Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
EPMA J. 2022 Feb 18;13(1):125-135. doi: 10.1007/s13167-022-00273-6. eCollection 2022 Mar.
A possible association between metabolic disorders and ambient temperature has been suggested, and cold exposure as a way of increasing energy expenditure has gained considerable interest for preventative/therapeutic measures toward metabolic disorders. Although thermal sensitivity, which has recently been studied in regard to its utility as a risk assessment/patient stratification for various diseases, might influence physiological responses to ambient temperature on an individual basis, more studies are needed. We aimed to investigate the association between self-identified thermal intolerance/sensation and metabolic syndrome (MetS) to verify the working hypothesis that individuals with altered thermal sensitivity may have a predisposition to MetS. We fitted generalized additive models for thermal intolerance/sensation using body mass index (BMI) and waist-hip ratio in women, and identified those with higher/lower thermal intolerance/sensation than those predicted by the models. Higher heat intolerance, higher heat sensation, and lower cold intolerance were associated with a higher prevalence of MetS. The risk of having MetS was increased in those who had two or three associated conditions compared with those with none of these conditions. In an analysis for MetS components, significant associations of thermal sensitivity were present with high glucose, triglyceride, and blood pressure levels. Overall, higher heat intolerance/sensation and lower cold intolerance were associated with increased prevalence of MetS even at a similar level of obesity. Our study indicates that evaluation of thermal sensitivity may help identify individuals at high risk for MetS, and lead to more advanced patient stratification and personalized treatment strategies for MetS, including cold-induced thermogenesis.
The online version contains supplementary material available at 10.1007/s13167-022-00273-6.
代谢紊乱与环境温度之间可能存在关联，将寒冷暴露作为增加能量消耗的一种方式，对于代谢紊乱的预防/治疗措施而言已引起了相当大的关注。尽管最近对热敏感性作为各种疾病风险评估/患者分层的效用进行了研究，但其可能会在个体层面影响对环境温度的生理反应，仍需要更多研究。我们旨在研究自我认定的热不耐受/热感觉与代谢综合征（MetS）之间的关联，以验证热敏感性改变的个体可能易患MetS这一工作假设。我们使用体重指数（BMI）和腰臀比为女性的热不耐受/热感觉拟合广义相加模型，并确定那些热不耐受/热感觉高于或低于模型预测值的个体。更高的热不耐受、更高的热感觉和更低的冷不耐受与MetS的更高患病率相关。与无这些相关情况的人相比，有两种或三种相关情况的人患MetS的风险增加。在对MetS各组分的分析中，热敏感性与高血糖、甘油三酯和血压水平存在显著关联。总体而言，即使在肥胖程度相似的情况下，更高的热不耐受/热感觉和更低的冷不耐受也与MetS患病率增加相关。我们的研究表明，评估热敏感性可能有助于识别MetS高危个体，并导致更先进的患者分层和针对MetS的个性化治疗策略，包括冷诱导产热。
在线版本包含可在10.1007/s13167-022-00273-6获取的补充材料。
