乳腺癌中感觉寒冷及其他被低估的症状：轶事还是用于晚期患者分层的个体特征？
Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification?
作者信息
Golubnitschaja Olga
机构信息
Radiological Clinic, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany.
Breast Cancer Research Centre, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany.
出版信息
EPMA J. 2017 Mar 8;8(1):17-22. doi: 10.1007/s13167-017-0086-6. eCollection 2017 Mar.
Abstract
Breast cancer (BC) epidemic is recognised as being characteristic for the early twenty-first century. BC is a multifactorial disease, and a spectrum of modifiable (preventable) factors significantly increasing risks has been described. This article highlights a series of underestimated symptoms for consequent BC risk assessment and patient stratification. Phenomena of the deficient thermoregulation, altered sensitivity to different stimuli (pain, thirst, smell, light, stress provocation), dehydration, altered circadian and sleep patterns, tendency towards headache, migraine attacks and dizziness, as well as local and systemic hypoxic effects are discussed for BC patients providing functional links and proposing new approaches in the overall BC management.
摘要
乳腺癌（BC）流行被认为是21世纪初的特征。乳腺癌是一种多因素疾病，一系列可改变（可预防）的因素被描述为会显著增加风险。本文强调了一系列被低估的症状，用于后续的乳腺癌风险评估和患者分层。本文讨论了乳腺癌患者体温调节不足、对不同刺激（疼痛、口渴、嗅觉、光线、应激刺激）的敏感性改变、脱水、昼夜节律和睡眠模式改变、头痛、偏头痛发作和头晕倾向，以及局部和全身缺氧效应等现象，提供了功能联系并提出了乳腺癌整体管理的新方法。
相似文献
1
Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification?乳腺癌中感觉寒冷及其他被低估的症状：轶事还是用于晚期患者分层的个体特征？
EPMA J. 2017 Mar 8;8(1):17-22. doi: 10.1007/s13167-017-0086-6. eCollection 2017 Mar.
2
Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach?乳腺癌与弗拉默综合征：在预测、预防和个性化医疗方法方面有共同症状吗？
EPMA J. 2017 Apr 10;8(2):129-140. doi: 10.1007/s13167-017-0089-3. eCollection 2017 Jun.
3
"Pre-metastatic niches" in breast cancer: are they created by or prior to the tumour onset? "Flammer Syndrome" relevance to address the question.乳腺癌中的“前转移微环境”：它们是在肿瘤发生之前就已形成，还是由肿瘤发生所导致？“弗拉默综合征”与解答该问题的相关性。
EPMA J. 2017 May 2;8(2):141-157. doi: 10.1007/s13167-017-0092-8. eCollection 2017 Jun.
4
Postmenopausal breast cancer: European challenge and innovative concepts.绝经后乳腺癌：欧洲面临的挑战与创新理念
EPMA J. 2017 May 30;8(2):159-169. doi: 10.1007/s13167-017-0094-6. eCollection 2017 Jun.
5
The potential relationship between Flammer and Sjögren syndromes: the chime of dysfunction.弗拉默综合征与干燥综合征之间的潜在关系：功能障碍的共鸣。
EPMA J. 2017 Aug 14;8(4):333-338. doi: 10.1007/s13167-017-0107-5. eCollection 2017 Dec.
6
Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions.前列腺癌管理：长期观念、21世纪初的流行趋势及三维解决方案
EPMA J. 2020 Jun 26;11(3):399-418. doi: 10.1007/s13167-020-00214-1. eCollection 2020 Sep.
7
Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach.年轻时中风易感性相关风险：基于个体化预测和预防方法的事实与假说
EPMA J. 2019 Feb 20;10(1):81-99. doi: 10.1007/s13167-019-00162-5. eCollection 2019 Mar.
8
"Dry mouth" and "Flammer" syndromes-neglected risks in adolescents and new concepts by predictive, preventive and personalised approach.“口干”与“弗拉默”综合征——青少年中被忽视的风险以及预测、预防和个性化方法的新概念
EPMA J. 2018 Aug 2;9(3):307-317. doi: 10.1007/s13167-018-0145-7. eCollection 2018 Sep.
9
Flammer syndrome.弗莱默综合征。
EPMA J. 2014 Jul 8;5(1):11. doi: 10.1186/1878-5085-5-11. eCollection 2014.
10
Relationship between normal tension glaucoma and Flammer syndrome.正常眼压性青光眼与弗拉默综合征之间的关系。
EPMA J. 2017 Jun 2;8(2):111-117. doi: 10.1007/s13167-017-0097-3. eCollection 2017 Jun.
引用本文的文献
1
Predictors of fatigue improvement in multimodal, multimodal-aerobic and aerobic exercise intervention studies in breast cancer survivors with cancer-related fatigue.在患有癌症相关疲劳的乳腺癌幸存者中，多模式、多模式有氧运动和有氧运动干预研究中疲劳改善的预测因素。
Sci Rep. 2025 Jul 1;15(1):20690. doi: 10.1038/s41598-025-06701-7.
2
Breast Cancer Cell Lines AT-3 and E0771 Decrease Mechanical and Cold Sensitivity, Along With Oestrous Cycle and Inflammatory Marker Alterations, in Wild-Type C57BL/6J Female Mice.乳腺癌细胞系AT-3和E0771降低野生型C57BL/6J雌性小鼠的机械敏感性和冷敏感性，同时伴有发情周期和炎症标志物改变。
Eur J Pain. 2025 Jul;29(6):e70066. doi: 10.1002/ejp.70066.
3
Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients.靶向丝裂原活化蛋白激酶（MAPK）信号通路：黄酮类化合物在3P医学中作为乳腺癌患者癌细胞可塑性和治疗抗性调节剂的意义与前景
EPMA J. 2025 Apr 10;16(2):437-463. doi: 10.1007/s13167-025-00407-6. eCollection 2025 Jun.
4
Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria.基于质谱分析法的外泌汗腺汗液分析为奥地利一组乳腺癌患者的预测性、预防性和个性化医疗提供了支持。
EPMA J. 2025 Jan 31;16(1):165-182. doi: 10.1007/s13167-025-00396-6. eCollection 2025 Mar.
5
Pain chronification risk assessment: advanced phenotyping and scoring for prediction and treatments tailored to individualized patient profile.疼痛慢性化风险评估：针对个体化患者特征进行预测和治疗的高级表型分析与评分
EPMA J. 2024 Nov 15;15(4):739-750. doi: 10.1007/s13167-024-00383-3. eCollection 2024 Dec.
6
Mitochondria-based holistic 3PM approach as the 'game-changer' for individualised rehabilitation-the proof-of-principle model by treated breast cancer survivors.基于线粒体的整体3PM方法作为个性化康复的“变革者”——乳腺癌幸存者治疗的原理验证模型
EPMA J. 2024 Nov 20;15(4):559-571. doi: 10.1007/s13167-024-00386-0. eCollection 2024 Dec.
7
Resting energy expenditure differs among individuals with different levels of perceived thermal sensitivity: A cross-sectional study.不同热敏感感知水平个体的静息能量消耗不同：一项横断面研究。
Medicine (Baltimore). 2024 May 24;103(21):e38293. doi: 10.1097/MD.0000000000038293.
8
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation.缺血性中风从反应性医疗服务到下午3点的范式转变：一种利用泪液多组学、线粒体作为重要生物传感器以及基于人工智能的多专业数据解读的整体方法。
EPMA J. 2024 Feb 27;15(1):1-23. doi: 10.1007/s13167-024-00356-6. eCollection 2024 Mar.
9
Predictive, preventive and personalised approach as a conceptual and technological innovation in primary and secondary care of inflammatory bowel disease benefiting affected individuals and populations.作为炎症性肠病初级和二级护理中的概念和技术创新，预测、预防和个性化方法使受影响的个体和人群受益。
EPMA J. 2024 Feb 9;15(1):111-123. doi: 10.1007/s13167-024-00351-x. eCollection 2024 Mar.
10
Diabetes, glycemic control and arterial stiffness: a real-world cohort study in the context of predictive, preventive, and personalized medicine.糖尿病、血糖控制与动脉僵硬度：在预测、预防和个性化医学背景下的一项真实世界队列研究
EPMA J. 2023 Nov 24;14(4):663-672. doi: 10.1007/s13167-023-00347-z. eCollection 2023 Dec.
本文引用的文献
1
Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon?乳腺癌患者脑转移疾病之谜：患者分层、疾病预测及靶向预防有望得到改善？
EPMA J. 2017 Mar 13;8(2):119-127. doi: 10.1007/s13167-017-0087-5. eCollection 2017 Jun.
2
Circadian gene variants and breast cancer.昼夜节律基因变异与乳腺癌。
Cancer Lett. 2017 Apr 1;390:137-145. doi: 10.1016/j.canlet.2017.01.012. Epub 2017 Jan 18.
3
Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme.多形性胶质母细胞瘤患者实验性靶向治疗和免疫治疗的进展
Anticancer Res. 2017 Jan;37(1):21-33. doi: 10.21873/anticanres.11285.
4
Prediction of Acute Postoperative Pain Following Breast Cancer Surgery Using the Pain Sensitivity Questionnaire: A Cohort Study.使用疼痛敏感性问卷预测乳腺癌手术后的急性术后疼痛：一项队列研究。
Clin J Pain. 2017 Jan;33(1):57-66. doi: 10.1097/AJP.0000000000000380.
5
Regular sun exposure benefits health.经常晒太阳对健康有益。
Med Hypotheses. 2016 Dec;97:34-37. doi: 10.1016/j.mehy.2016.10.011. Epub 2016 Oct 19.
6
Epidemiology for primary brain tumors: a nationwide population-based study.原发性脑肿瘤的流行病学：一项基于全国人口的研究。
J Neurooncol. 2017 Feb;131(3):525-546. doi: 10.1007/s11060-016-2318-3. Epub 2016 Nov 16.
7
Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016.21世纪初的医学：范式与展望——欧洲临床化学和检验医学联合会2016年立场文件
EPMA J. 2016 Oct 25;7(1):23. doi: 10.1186/s13167-016-0072-4. eCollection 2016.
8
Dissecting the Origin of Breast Cancer Subtype Stem Cell and the Potential Mechanism of Malignant Transformation.剖析乳腺癌亚型干细胞的起源及恶性转化的潜在机制。
PLoS One. 2016 Oct 21;11(10):e0165001. doi: 10.1371/journal.pone.0165001. eCollection 2016.
9
The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer.昼夜节律基因Arntl2是雌激素受体阴性乳腺癌的转移易感基因。
PLoS Genet. 2016 Sep 22;12(9):e1006267. doi: 10.1371/journal.pgen.1006267. eCollection 2016 Sep.
10
Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures.21世纪初的乳腺癌流行：风险因素评估、累积问卷调查及预防措施建议
Tumour Biol. 2016 Oct;37(10):12941-12957. doi: 10.1007/s13277-016-5168-x. Epub 2016 Jul 22.
Zotero 插件