Rais Ghizlane, Ziouziou Imad, Wakrim Soukaina, Serhane Hind
Medical oncology department, Faculty of medicine and pharmacy of Agadir, University Ibn Zohr Agadir, 102, Res Yasmine, Rue Alikhlass, Quartier Najah, Agadir, 80000, Morocco.
Urology department, Faculty of medicine and pharmacy of Agadir, University Ibn Zohr Agadir, Morocco.
Radiol Case Rep. 2022 Mar 2;17(5):1450-1456. doi: 10.1016/j.radcr.2022.02.022. eCollection 2022 May.
Tumor-to-tumor metastasis (TTM) is a well-known entity, although this is still an extremely rare phenomenon. The lung cancers are considered the most frequent metastatic donors while kidney cancers are the most common recipient. The finding of TTM is often incidental during a biopsy of metastases or on surgical specimens but never suspected on radiological assessment of tumor extension. The finding of an unexpected region of Fluorodeoxyglucose (FDG) uptake can occur when performing whole body Positron Emission Tomography/computed tomography (PET/CT) scan and potentially raises the possibility of a second primary tumor. However, PET/CT scan incidental detection of tumor-to-tumor metastasis has never been reported in English literature. We report here a case of clear cell renal carcinoma, receptor of metastases originating from an oligometastatic squamous cell lung cancer detected on the PET/CT scan performed as part of the extension workup. Morphological and immunohistochemical analysis of a percutaneous biopsy of the renal mass were consistent with the diagnosis of a metastasis of lung cancer into renal cell carcinoma. This is the first case of oligometastatic lung cancer with the occurrence of TTM suspected in PET/CT scan. Although this is a rare setting, it should be considered in daily practice, as it could potentially modify the oncological management offered to the patients.
肿瘤-to-肿瘤转移（TTM）是一种已知的现象，尽管这仍然是极为罕见的情况。肺癌被认为是最常见的转移源，而肾癌则是最常见的转移受体。TTM的发现通常在转移灶活检或手术标本检查时偶然出现，但在肿瘤范围的影像学评估中从未被怀疑过。在进行全身正电子发射断层扫描/计算机断层扫描（PET/CT）时，可能会发现意外的氟脱氧葡萄糖（FDG）摄取区域，这可能会增加第二原发性肿瘤的可能性。然而，英文文献中从未报道过PET/CT扫描偶然发现肿瘤-to-肿瘤转移的情况。我们在此报告一例透明细胞肾细胞癌病例，该转移灶受体源自作为分期检查一部分进行的PET/CT扫描中检测到的寡转移鳞状细胞肺癌。对肾肿块进行经皮活检的形态学和免疫组化分析与肺癌转移至肾细胞癌的诊断一致。这是首例在PET/CT扫描中怀疑发生TTM的寡转移肺癌病例。尽管这种情况罕见，但在日常实践中应予以考虑，因为它可能会改变为患者提供的肿瘤治疗方案。
