Furia Simone, Nicole' Lorenzo, Laurino Licia, Breda Cristiano
Thoracic Surgery, Ospedale dell'Angelo, Venezia-Mestre, ITA.
Pathology, Ospedale dell'Angelo, Venezia-Mestre, ITA.
Cureus. 2023 Jan 9;15(1):e33537. doi: 10.7759/cureus.33537. eCollection 2023 Jan.
Tumor-to-tumor metastasis is defined as when metastasis from a primary tumor (donor) grows in a different primary neoplasm (recipient). Due to the structure of the thymus and the low incidence rate, thymic epithelial neoplasm has been rarely described in the literature as a recipient for metastases.In this report,a patient with advanced prostatic cancer and under control after chemo/hormone therapy was directed to our thoracic surgery unit for an anterior mediastinal mass detected during the staging workup for prostate disease. A limited uptake at fluorodeoxyglucose-positron emission tomography (FDG-PET) in the mediastinal lesion, while the surrounding tissue showed diffusely negative hypermetabolism, suggested a second primary thymic epithelial tumor with a possible carcinomatous differentiation. A thymectomy through a median sternotomy was carried out. Histopathological analysis after thymectomy revealed a type A thymoma with multiple elements of prostate adenocarcinoma within it. The foci of prostate adenocarcinoma were co-located in the context of the thymoma, revealing what is defined as a tumor-to-tumor metastasis.To our knowledge, this is the first report describing a thymoma as the recipient of metastases coming from a primary extrathoracic tumor without the involvement of other thoracic organs.
肿瘤-to-肿瘤转移被定义为原发性肿瘤（供体）的转移灶在另一种原发性肿瘤（受体）中生长。由于胸腺的结构和低发病率，胸腺上皮肿瘤作为转移受体在文献中很少被描述。在本报告中，一名晚期前列腺癌患者在接受化疗/激素治疗后病情得到控制，因在前列腺疾病分期检查中发现前纵隔肿块而被转诊至我们的胸外科。纵隔病变在氟脱氧葡萄糖-正电子发射断层扫描（FDG-PET）中摄取有限，而周围组织显示弥漫性阴性高代谢，提示为具有可能癌变分化的第二原发性胸腺上皮肿瘤。通过正中胸骨切开术进行了胸腺切除术。胸腺切除术后的组织病理学分析显示为A型胸腺瘤，其中含有多个前列腺腺癌成分。前列腺腺癌灶与胸腺瘤并存，揭示了所谓的肿瘤-to-肿瘤转移。据我们所知，这是第一份描述胸腺瘤作为来自胸外原发性肿瘤转移受体且无其他胸部器官受累的报告。
