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对环丙沙星过敏导致紧急手术行环甲膜切开术

Anaphylaxis to Ciprofloxacin Requiring Emergent Surgical Cricothyrotomy.

作者信息

Tang Wesley, Rao Edwina

机构信息

Department of Medicine, Kettering Medical Center, Kettering, OH, USA.

出版信息

Eur J Case Rep Intern Med. 2022 Feb 24;9(2):003180. doi: 10.12890/2022_003180. eCollection 2022.

DOI:10.12890/2022_003180
PMID:35265553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8900558/
Abstract

UNLABELLED

Although allergies to antibiotics are commonly stated, anaphylactic reactions are uncommonly reported. This is especially the case with reactions to fluoroquinolone antibiotics. Furthermore, airway emergencies are rare. We present a case of ciprofloxacin-induced acute airway obstruction and anaphylaxis, necessitating emergent surgical cricothyrotomy following respiratory distress.

LEARNING POINTS

Anaphylactic reactions to fluoroquinolone antibiotics are extremely rare.There are currently no standardized diagnostic tests, making the diagnosis of anaphylaxis challenging and largely based on history alone.Treating clinicians should be aware of this rare, but potentially rapidly fatal adverse drug reaction.

摘要

未标注

虽然对抗生素过敏的情况很常见,但过敏性反应的报告却很少见。氟喹诺酮类抗生素引起的反应尤其如此。此外,气道紧急情况很少见。我们报告一例环丙沙星引起的急性气道梗阻和过敏反应,患者在出现呼吸窘迫后需要紧急进行外科环甲膜切开术。

学习要点

氟喹诺酮类抗生素引起的过敏反应极为罕见。目前尚无标准化的诊断测试,这使得过敏反应的诊断具有挑战性,且很大程度上仅基于病史。临床治疗医生应意识到这种罕见但可能迅速致命的药物不良反应。

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Outpatient fluoroquinolone prescribing patterns before and after US FDA boxed warning.美国食品药品监督管理局发布警示通告前后的门诊氟喹诺酮类药物处方模式。
Pharmacoepidemiol Drug Saf. 2020 Jun;29(6):701-707. doi: 10.1002/pds.5018. Epub 2020 May 11.
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Update on Quinolone Allergy.喹诺酮类药物过敏的最新情况。
Curr Allergy Asthma Rep. 2017 Aug;17(8):56. doi: 10.1007/s11882-017-0725-y.
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Usefulness of In Vivo and In Vitro Diagnostic Tests in the Diagnosis of Hypersensitivity Reactions to Quinolones and in the Evaluation of Cross-Reactivity: A Comprehensive Study Including the Latest Quinolone Gemifloxacin.
体内和体外诊断测试在喹诺酮类过敏反应诊断及交叉反应评估中的效用:一项纳入最新喹诺酮类药物吉米沙星的综合研究
Allergy Asthma Immunol Res. 2017 Jul;9(4):347-359. doi: 10.4168/aair.2017.9.4.347.
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