Kaderli Sema Tamer, Hazirolan Dicle, Uney Guner, Kaderli Ahmet, Unlu Nurten, Acar Mehmet Akif, Ornek Firdevs
Department of Ophthalmology, Mugla Training and Research Hospital, Mugla, Turkey.
Department of Ophthalmology, University of Health Sciences Ankara Training and Research Hospital, Ankara, Turkey.
Beyoglu Eye J. 2022 Feb 18;7(1):39-46. doi: 10.14744/bej.2021.60590. eCollection 2022.
To assess multifocal electroretinogram (mf-ERG) values in patients with diabetic macular edema (DME) who were treated with intravitreal ranibizumab (IVR).
Thirty eyes of patients with DME, who underwent three consecutive monthly injections of IVR and as required thereafter, were evaluated. Best corrected visual acuity (BCVA) (log MAR), optical coherence tomography (OCT) features [diameters of cyst and subretinal fluid, hyperreflective dots (HRDs)], and mf-ERG were evaluated at baseline, 1 month, and 6 months throughout the follow-up period. The correlation of mf-ERG values and OCT features, BCVA, and the duration of disease were investigated.
In the study group, the baseline P1 and N1 amplitudes were significantly lower than the control group, and P1 and N1 implicit times were significantly higher in patients with DME than in the control group in all rings (All p<0.05) The mean response density (P1 amplitude, nV/deg) values increased over 6 months in rings 1, 2, and 3 (p<0.001, p=0.003, p=0.006). There was a negative correlation between the diameter of the cyst and the initial response density of P1 (for horizontal diameter: r=-0.658, p=0.03; for vertical diameter: r=-0.597, p=0.037; for the area of the cyst, r=-0.603, p=0.021). There was a significant negative correlation between the subretinal fluid and HRD reduction and the response density of P1 increase (all p<0.05). At baseline and 6 months, the correlation between BCVA and the P1 and N1 amplitude of the central ring was significant (for baseline P1: r=-0.649, p=0.01; for N1: r=-0.575, p=0.02; for 6-month P1, r=-0.603, p<0.001; for N1: r=-0.591, p=0.005).
The combination of OCT and mf-ERG can be used to evaluate the functional recovery in DME.
评估玻璃体内注射雷珠单抗（IVR）治疗的糖尿病性黄斑水肿（DME）患者的多焦视网膜电图（mf-ERG）值。
对30例接受连续3个月每月一次IVR注射且此后按需注射的DME患者的眼进行评估。在整个随访期的基线、1个月和6个月时评估最佳矫正视力（BCVA）（对数最小分辨角）、光学相干断层扫描（OCT）特征[囊肿和视网膜下液直径、高反射点（HRD）]以及mf-ERG。研究mf-ERG值与OCT特征、BCVA和病程之间的相关性。
在研究组中，DME患者所有环的基线P1和N1振幅均显著低于对照组，且P1和N1隐时均显著高于对照组（所有p<0.05）。1、2和3环的平均反应密度（P1振幅，nV/deg）值在6个月内有所增加（p<0.001，p=0.003，p=0.006）。囊肿直径与P1初始反应密度之间存在负相关（水平直径：r=-0.658，p=0.03；垂直直径：r=-0.597，p=0.037；囊肿面积：r=-0.603，p=0.021）。视网膜下液和HRD减少与P1反应密度增加之间存在显著负相关（所有p<0.05）。在基线和6个月时，BCVA与中央环的P1和N1振幅之间存在显著相关性（基线P1：r=-0.649，p=0.01；N1：r=-0.575，p=0.02；6个月时P1，r=-0.603，p<0.001；N1：r=-0.591，p=0.005）。
OCT和mf-ERG联合应用可用于评估DME的功能恢复情况。
