Neurology Department, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Imagenology Department, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
J Neurooncol. 2022 Apr;157(2):377-382. doi: 10.1007/s11060-022-03972-2. Epub 2022 Mar 10.
Diffuse Brainstem Glioma (DBG) is a catastrophic brain tumor with a survival rate of less than 10% two years after diagnosis despite the existence of different treatment protocols. Among the devices that use magnetic fields generated by Magnetic Resonance Imaging is Quantum Magnetic Resonance Therapy (QMRT).
Five children diagnosed with DBG in our institution in Mexico City underwent treatment of compassionate use with QMRT between December 2018 and July 2019. A survival analysis was performed with previously reported historical data (n = 15).
Two patients (40%) survived after three years of follow-up; the log-rank test showed a statistically significant difference in overall survival between both groups (p = 0.032). All patients tolerated the treatment adequately without reporting any severe clinical or neuroradiological adverse effects. Of the patients included, all showed a decrease in the tumor one month after the end of the treatment, although there was great variability in the response and the difference was not statistically significant (p = 0.06).
Although future investigations are needed to confirm the findings reported in the present study, the improvement in survival is promising for a group of patients whose prognosis has been catastrophic over the years. Trial registration NCT03577600.
弥漫性脑桥胶质瘤（DBG）是一种灾难性的脑肿瘤，尽管存在不同的治疗方案，但在诊断后两年的生存率仍低于 10%。在利用磁共振成像产生的磁场的设备中，有一种是量子磁共振治疗（QMRT）。
在墨西哥城的我们机构，5 名被诊断为 DBG 的儿童在 2018 年 12 月至 2019 年 7 月期间接受了 QMRT 的同情使用治疗。对之前报告的历史数据（n=15）进行了生存分析。
2 名患者（40%）在随访 3 年后存活；对数秩检验显示两组患者的总体生存率存在统计学差异（p=0.032）。所有患者均能耐受治疗，无严重临床或神经放射学不良事件报告。在纳入的患者中，所有患者在治疗结束后一个月肿瘤均有缩小，尽管反应存在很大差异，但差异无统计学意义（p=0.06）。
尽管需要进一步的研究来证实本研究报告的结果，但对于多年来预后一直较差的患者群体来说，生存率的提高是有希望的。试验注册 NCT03577600。
