Engineering of Molecular NanoSystems, Ecole Polytechnique de Bruxelles, Université libre de Bruxelles, Avenue F. D. Roosevelt 50, CP165/64, 1050, Brussels, Belgium.
Laboratoire de Chimie Organique, Avenue F. D. Roosevelt 50, CP160/06, 1050, Brussels, Belgium.
Chempluschem. 2022 Apr;87(4):e202200043. doi: 10.1002/cplu.202200043. Epub 2022 Mar 9.
Invited for this month's cover are the collaborating groups of Prof. Gilles Bruylants and Prof. Ivan Jabin, Université libre de Bruxelles, Belgium. The cover picture shows the principle of a colorimetric sensor, based on peptide-conjugated silver nanoparticles, for the detection of the cancer biomarker Mdm2. The particles were functionalized via a recently developed strategy based on the use of calixarene diazonium salts. The calixarene-based coating provides an unprecedented stability to the silver nanoparticles, enabling their use as colorimetric reporters for in vitro diagnostics. The cover was designed by I. Jabin. More information can be found in the Research Article by I. Jabin, G. Bruylants, and co-workers.
本月的封面邀请到了比利时布鲁塞尔自由大学 Gilles Bruylants 教授和 Ivan Jabin 教授的合作团队。该封面图片展示了基于肽偶联银纳米粒子的比色传感器检测癌症生物标志物 Mdm2 的原理。通过最近开发的一种基于使用杯芳烃重氮盐的策略对纳米粒子进行功能化。基于杯芳烃的涂层为银纳米粒子提供了前所未有的稳定性，使其能够用作体外诊断的比色报告物。封面由 I. Jabin 设计。有关更多信息，请参阅 I. Jabin、G. Bruylants 及其同事的研究文章。
