School of Public Health, Jilin University, Changchun, Jilin 130021, China.
ACS Appl Mater Interfaces. 2022 Mar 23;14(11):12984-13000. doi: 10.1021/acsami.1c22629. Epub 2022 Mar 10.
Wound healing greatly affects patients' health and produces medical burden. Therefore, we developed a multifunctional electrospun nanofiber dressing, which can inhibit methicillin-resistant (MRSA), drain excessive biofluid to promote wound healing, and simultaneously monitor wound pH level. The polyoxometalate (α-KPWO·14HO, PW) and oxacillin (OXA) are encapsulated in hydrophobic polylactide (PLA) nanofiber to synergistically inhibit MRSA. The phenol red (PSP) is encapsulated in hydrophilic polyacrylonitrile (PAN) nanofiber to sensitively indicate wound pH . The PSP/PAN nanofiber is directly electrospun on the patterning OXA/PW/PLA nanofiber layer to form a Janus dressing. By taking advantage of the wettability difference between the two layers, the excess biofluid can be drained away from the wound. In addition, the Janus dressing exhibits good biocompatibility and accelerates wound healing via its antimicrobial activity and skin repairing function. This multifunctional Janus electrospun nanofiber dressing would be beneficial for wound management and treatment.
创伤愈合极大地影响患者的健康并产生医疗负担。因此，我们开发了一种多功能电纺纳米纤维敷料，它可以抑制耐甲氧西林金黄色葡萄球菌（MRSA），排出过多的生物流体以促进伤口愈合，同时监测伤口的 pH 值。多金属氧酸盐（α-KPWO·14HO，PW）和苯唑西林（OXA）被包裹在疏水性聚乳酸（PLA）纳米纤维中，以协同抑制 MRSA。酚红（PSP）被包裹在亲水性聚丙烯腈（PAN）纳米纤维中，以灵敏地指示伤口 pH 值。PSP/PAN 纳米纤维直接电纺在图案化的 OXA/PW/PLA 纳米纤维层上，形成 Janus 敷料。利用两层之间的润湿性差异，可以将过多的生物流体从伤口中排出。此外，Janus 敷料通过其抗菌活性和皮肤修复功能表现出良好的生物相容性并加速伤口愈合。这种多功能的 Janus 电纺纳米纤维敷料将有益于伤口管理和治疗。
