Wang Xueqi, Cheng Jing, Wang Han
School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.
National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China.
Microsyst Nanoeng. 2024 Dec 16;10(1):193. doi: 10.1038/s41378-024-00801-6.
Chronic wounds, which require prolonged healing periods, pose significant impacts on individuals with diabetes, vascular diseases, and high blood pressure. Simultaneous drainage and monitoring of wound exudate are vital for advanced wound management. However, recently reported smart dressings either lack integration of wound cleaning and monitoring functions or fail to achieve dynamic in situ monitoring of wound status, which hinders their ability to meet the demands of wound care. In this study, a smart bandage is introduced, which integrates a biocompatible liquid diode membrane with an ultrasensitive 3D polyaniline mesh (M-PANI)-based pH biosensor. The smart bandage allows for unidirectional drainage of wound exudate while dynamically sensing the wound pH environment. Specifically, the proposed smart bandage effectively cleans excessive wound exudate while providing real-time information on the wound status during the drainage process. The M-PANI-based pH biosensor demonstrates a high sensitivity of 61.5 mV/pH and a wide pH detection range from 4.0 to 10.0, encompassing the pH range of normal and infected wounds. Moreover, the sensing module exhibits excellent stability after 48 hours of dynamic testing and 28 days of storage, with only a 4.8% decline in the detected signal, and high repeatability with a device-to-device relative standard deviation (RSD) of 3.1%. To evaluate the practicality of this smart bandage, simulated skin and rats have been employed, and the results indicate the immense potential of this smart bandage for clinical applications. In conclusion, the present smart bandage demonstrates considerable promise for wound exudate cleaning and monitoring in advanced wound care and offers a promising method for home-based wound management.
慢性伤口需要较长的愈合时间，对糖尿病、血管疾病和高血压患者产生重大影响。同时引流和监测伤口渗出液对于先进的伤口管理至关重要。然而，最近报道的智能敷料要么缺乏伤口清洁和监测功能的整合，要么未能实现对伤口状态的动态原位监测，这阻碍了它们满足伤口护理需求的能力。在本研究中，引入了一种智能绷带，它将生物相容性液体二极管膜与基于超灵敏三维聚苯胺网（M-PANI）的pH生物传感器集成在一起。这种智能绷带允许伤口渗出液单向引流，同时动态感知伤口的pH环境。具体而言，所提出的智能绷带在有效清理过多伤口渗出液的同时，还能在引流过程中提供有关伤口状态的实时信息。基于M-PANI的pH生物传感器具有61.5 mV/pH的高灵敏度和4.0至10.0的宽pH检测范围，涵盖正常伤口和感染伤口的pH范围。此外，传感模块在经过48小时动态测试和28天储存后表现出出色的稳定性，检测信号仅下降4.8%，并且具有3.1%的设备间相对标准偏差（RSD）的高重复性。为了评估这种智能绷带的实用性，已使用模拟皮肤和大鼠进行实验，结果表明这种智能绷带在临床应用中具有巨大潜力。总之，目前的智能绷带在先进伤口护理中的伤口渗出液清洁和监测方面显示出巨大潜力，并为家庭伤口管理提供了一种有前景的方法。
