Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Weems Design Studio, Inc, Contractor assigned to Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Infect Dis. 2022 Jun 1;225(11):1871-1875. doi: 10.1093/infdis/jiac046.
Historically, antimicrobial resistance has been rare in US invasive meningococcal disease cases.
Meningococcal isolates (n = 695) were collected through population-based surveillance, 2012-2016, and national surveillance, 2015-2016. Antimicrobial susceptibility was assessed by broth microdilution. Resistance mechanisms were characterized using whole-genome sequencing.
All isolates were susceptible to 6 antibiotics (cefotaxime, ceftriaxone, meropenem, rifampin, minocycline, and azithromycin). Approximately 25% were penicillin or ampicillin intermediate; among these, 79% contained mosaic penA gene mutations. Less than 1% of isolates were penicillin, ampicillin, ciprofloxacin, or levofloxacin resistant.
Penicillin- and ampicillin-intermediate isolates were common, but resistance to clinically relevant antibiotics remained rare.
在美国，侵袭性脑膜炎奈瑟菌病病例中，抗生素耐药性历来罕见。
通过基于人群的监测（2012-2016 年）和全国性监测（2015-2016 年）收集了脑膜炎奈瑟菌分离株（n=695）。采用肉汤微量稀释法评估抗菌药物敏感性。使用全基因组测序来鉴定耐药机制。
所有分离株均对 6 种抗生素（头孢噻肟、头孢曲松、美罗培南、利福平、米诺环素和阿奇霉素）敏感。约 25%的分离株对青霉素或氨苄西林呈中介；其中 79%含有镶嵌 penA 基因突变。不到 1%的分离株对青霉素、氨苄西林、环丙沙星或左氧氟沙星耐药。
青霉素和氨苄西林中介分离株很常见，但对临床相关抗生素的耐药性仍然罕见。
