环丙沙星、头孢噻肟、头孢曲松、氯霉素和利福平对完全敏感及中度耐青霉素的脑膜炎奈瑟菌的体外活性。
In vitro activities of ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, and rifampin against fully susceptible and moderately penicillin-resistant Neisseria meningitidis.
作者信息
Blondeau J M, Yaschuk Y
机构信息
Department of Clinical Microbiology, St. Paul's Hospital (Grey Nuns') Saskatoon, Saskatchewan, Canada.
出版信息
Antimicrob Agents Chemother. 1995 Nov;39(11):2577-9. doi: 10.1128/AAC.39.11.2577.
Abstract
Moderately penicillin-resistant Neisseria meningitidis was responsible for an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada in 1993. We tested fully susceptible and moderately resistant strains of N. meningitidis against ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, penicillin, and rifampin. Eighteen percent of the isolates were moderately resistant to penicillin (MIC > or = 0.06 microgram/ml) whereas susceptibility was 100% for the other agents tested.
摘要
1993年，中度耐青霉素的脑膜炎奈瑟菌在加拿大萨斯喀彻温省萨斯卡通市引发了一场脑膜炎球菌病疫情。我们对完全敏感和中度耐药的脑膜炎奈瑟菌菌株进行了环丙沙星、头孢噻肟、头孢曲松、氯霉素、青霉素和利福平的测试。18%的分离株对青霉素中度耐药（最低抑菌浓度≥0.06微克/毫升），而对其他测试药物的敏感性为100%。
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