More Satish G, Suryavanshi Gurunath
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune, 411 008, India.
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201 002, India.
Org Biomol Chem. 2022 Mar 23;20(12):2518-2529. doi: 10.1039/d2ob00213b.
Scandium triflate (Sc(OTf)) catalyzed, mild, and regioselective ring-opening reaction of donor-acceptor (D-A) cyclopropanes has been developed using sulfoximines for the synthesis of γ-sulfoximino malonic diesters. This protocol allows the synthesis of different -alkyl sulfoximines in good to excellent yields (up to 94%) with broad functional group tolerance. In this process, N-H and C-C bonds are cleaved to form new C-N and C-H bonds. The feasibility of this method is supported by a gram-scale reaction and synthetic elaboration of the obtained product.
已开发出一种使用亚砜亚胺，由三氟甲磺酸钪（Sc(OTf)）催化的温和且区域选择性的给体-受体（D-A）环丙烷开环反应，用于合成γ-亚砜亚胺基丙二酸二酯。该方法能以良好至优异的产率（高达94%）合成不同的烷基亚砜亚胺，且对官能团具有广泛的耐受性。在此过程中，N-H键和C-C键断裂，形成新的C-N键和C-H键。克级规模反应以及对所得产物的合成精制证明了该方法的可行性。
