Thangamani Murugesan, Srinivasan Kannupal
School of Chemistry, Bharathidasan University, Tiruchirappalli, Tamil Nadu 620 024, India.
J Org Chem. 2021 Jan 1;86(1):1172-1177. doi: 10.1021/acs.joc.0c02105. Epub 2020 Nov 25.
The reaction of aroyl-substituted donor-acceptor (D-A) cyclopropanes with two equivalents of 1-naphthylamines in the presence of a catalytic amount of scandium(III) triflate provides access to dibenzo[,]acridines. The key steps of the transformation are the formation of nucleophilic ring-opening products from the D-A cyclopropanes and 1-naphthylamines and their subsequent fragmentation and cyclization. The method has a reasonable substrate scope, and the products are formed in 50-70% yields.
在催化量的三氟甲磺酸钪存在下，芳酰基取代的供体-受体（D-A）环丙烷与两当量的1-萘胺反应可生成二苯并[，]吖啶。该转化的关键步骤是由D-A环丙烷和1-萘胺形成亲核开环产物，以及它们随后的碎片化和环化。该方法具有合理的底物范围，产物产率为50-70%。
