• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高臭氧油预防癌症复发的疗效：作用机制与临床证据

Efficacy of High-Ozonide Oil in Prevention of Cancer Relapses Mechanisms and Clinical Evidence.

作者信息

Izzotti Alberto, Fracchia Enzo, Rosano Camillo, Comite Antonio, Belgioia Liliana, Sciacca Salvatore, Khalid Zumama, Congiu Matteo, Colarossi Cristina, Blanco Giusi, Santoro Antonio, Chiara Massimo, Pulliero Alessandra

机构信息

Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.

IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

出版信息

Cancers (Basel). 2022 Feb 24;14(5):1174. doi: 10.3390/cancers14051174.

DOI:10.3390/cancers14051174
PMID:35267482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8909345/
Abstract

BACKGROUND

Cancer tissue is characterized by low oxygen availability triggering neo angiogenesis and metastatisation. Accordingly, oxidation is a possible strategy for counteracting cancer progression and relapses. Previous studies used ozone gas, administered by invasive methods, both in experimental animals and clinical studies, transiently decreasing cancer growth. This study evaluated the effect of ozonized oils (administered either topically or orally) on cancer, exploring triggered molecular mechanisms.

METHODS

In vitro, in lung and glioblastoma cancer cells, ozonized oils having a high ozonide content suppressed cancer cell viability by triggering mitochondrial damage, intracellular calcium release, and apoptosis. In vivo, a total of 115 cancer patients (age 58 ± 14 years; 44 males, 71 females) were treated with ozonized oil as complementary therapy in addition to standard chemo/radio therapeutic regimens for up to 4 years.

RESULTS

Cancer diagnoses were brain glioblastoma, pancreas adenocarcinoma, skin epithelioma, lung cancer (small and non-small cell lung cancer), colon adenocarcinoma, breast cancer, prostate adenocarcinoma. Survival rate was significantly improved in cancer patients receiving HOO as integrative therapy as compared with those receiving standard treatment only.

CONCLUSIONS

These results indicate that ozonized oils at high ozonide may represent an innovation in complementary cancer therapy worthy of further clinical studies.

摘要

背景

癌组织的特征是氧供应不足，这会引发新生血管形成和转移。因此，氧化是对抗癌症进展和复发的一种可能策略。先前的研究在实验动物和临床研究中使用侵入性方法给予臭氧气体，可短暂抑制癌症生长。本研究评估了臭氧油（局部或口服给药）对癌症的影响，并探索其引发的分子机制。

方法

在体外，对于肺癌和胶质母细胞瘤癌细胞，具有高臭氧化物含量的臭氧油通过引发线粒体损伤、细胞内钙释放和细胞凋亡来抑制癌细胞活力。在体内，共有115名癌症患者（年龄58±14岁；男性44名，女性71名）在标准化疗/放疗方案的基础上，接受臭氧油作为辅助治疗长达4年。

结果

癌症诊断包括脑胶质母细胞瘤、胰腺腺癌、皮肤上皮瘤、肺癌（小细胞肺癌和非小细胞肺癌）、结肠腺癌、乳腺癌、前列腺腺癌。与仅接受标准治疗的癌症患者相比，接受高臭氧化物含量臭氧油作为综合治疗的患者生存率显著提高。

结论

这些结果表明，高臭氧化物含量的臭氧油可能代表了辅助癌症治疗方面的一项创新，值得进一步开展临床研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/2b726339186b/cancers-14-01174-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/6b0ee4eb72c4/cancers-14-01174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/d80e9d625f54/cancers-14-01174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/a96993ddfc18/cancers-14-01174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/3d35a38dd18b/cancers-14-01174-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/4d854d00781d/cancers-14-01174-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/2f203562ad9c/cancers-14-01174-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/bf170cb779fd/cancers-14-01174-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/3c638d8059cb/cancers-14-01174-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/9d72fd9a2e6b/cancers-14-01174-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/3c64fa2e4a31/cancers-14-01174-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/4e5afc341b0d/cancers-14-01174-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/baae2c960f3d/cancers-14-01174-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/52cd13a4bdf4/cancers-14-01174-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/1bcb8ca451eb/cancers-14-01174-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/404602ed9e1f/cancers-14-01174-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/d509938f9f4c/cancers-14-01174-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/45ac28373666/cancers-14-01174-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/34c36442cc53/cancers-14-01174-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/2b726339186b/cancers-14-01174-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/6b0ee4eb72c4/cancers-14-01174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/d80e9d625f54/cancers-14-01174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/a96993ddfc18/cancers-14-01174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/3d35a38dd18b/cancers-14-01174-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/4d854d00781d/cancers-14-01174-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/2f203562ad9c/cancers-14-01174-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/bf170cb779fd/cancers-14-01174-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/3c638d8059cb/cancers-14-01174-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/9d72fd9a2e6b/cancers-14-01174-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/3c64fa2e4a31/cancers-14-01174-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/4e5afc341b0d/cancers-14-01174-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/baae2c960f3d/cancers-14-01174-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/52cd13a4bdf4/cancers-14-01174-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/1bcb8ca451eb/cancers-14-01174-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/404602ed9e1f/cancers-14-01174-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/d509938f9f4c/cancers-14-01174-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/45ac28373666/cancers-14-01174-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/34c36442cc53/cancers-14-01174-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c1/8909345/2b726339186b/cancers-14-01174-g019.jpg

相似文献

1
Efficacy of High-Ozonide Oil in Prevention of Cancer Relapses Mechanisms and Clinical Evidence.高臭氧油预防癌症复发的疗效：作用机制与临床证据
Cancers (Basel). 2022 Feb 24;14(5):1174. doi: 10.3390/cancers14051174.
2
Prevention of Covid-19 Infection and Related Complications by Ozonized Oils.臭氧油预防新冠病毒感染及相关并发症
J Pers Med. 2021 Mar 22;11(3):226. doi: 10.3390/jpm11030226.
3
Ozonation of sunflower oils: impact of experimental conditions on the composition and the antibacterial activity of ozonized oils.向日葵油的臭氧化：实验条件对臭氧化油的成分及抗菌活性的影响。
Chem Phys Lipids. 2015 Feb;186:79-85. doi: 10.1016/j.chemphyslip.2015.01.004. Epub 2015 Jan 23.
4
Gas chromatography-mass spectrometry profile of urinary organic acids of Wistar rats orally treated with ozonized unsaturated triglycerides and ozonized sunflower oil.经臭氧化不饱和甘油三酯和臭氧化葵花籽油口服处理的Wistar大鼠尿有机酸的气相色谱-质谱图谱。
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 15;783(2):517-25. doi: 10.1016/s1570-0232(02)00707-9.
5
Evaluation of ozonized calcium hydroxide as an effective intracanal medicament during root canal procedures: an observational study.根管治疗过程中臭氧氢氧化钙作为一种有效根管内药物的评价：一项观察性研究。
Med Gas Res. 2020 Jul-Sep;10(3):122-124. doi: 10.4103/2045-9912.296042.
6
[Effect of ozonized saline on signaling passway of Keap1-Nrf2-ARE in rat hepatocytes].[臭氧生理盐水对大鼠肝细胞中Keap1-Nrf2-ARE信号通路的影响]
Zhonghua Gan Zang Bing Za Zhi. 2011 May;19(5):367-71. doi: 10.3760/cma.j.issn.1007-3418.2011.05.013.
7
Ozonized oils: a qualitative and quantitative analysis.臭氧油：定性与定量分析
Braz Dent J. 2011;22(1):37-40. doi: 10.1590/s0103-64402011000100006.
8
The use of ozonized oil in the treatment of dermatophitosis caused by microsporum canis in rabbits.臭氧油治疗兔小孢子菌引起的皮肤癣菌病。
Braz J Microbiol. 2011 Jan;42(1):274-81. doi: 10.1590/S1517-83822011000100035.
9
Intravenous ozonized saline therapy as prophylaxis for healthcare workers (HCWs) in a dedicated COVID-19 hospital in India - A retrospective study.静脉注射臭氧生理盐水疗法作为印度一家专门的 COVID-19 医院医护人员（HCWs）的预防措施-一项回顾性研究。
Eur Rev Med Pharmacol Sci. 2021 May;25(9):3632-3639. doi: 10.26355/eurrev_202105_25847.
10
Products of ozonized arachidonic acid potentiate the formation of DNA single strand breaks in cultured human lung cells.臭氧处理的花生四烯酸产物增强培养的人肺细胞中DNA单链断裂的形成。
Environ Mol Mutagen. 1996;27(3):185-95. doi: 10.1002/(SICI)1098-2280(1996)27:3<185::AID-EM3>3.0.CO;2-E.

引用本文的文献

1
Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study.臭氧治疗对化疗引起的周围神经病变继发持续性麻木和刺痛患者的长期影响。一项回顾性研究。
Integr Cancer Ther. 2025 Jan-Dec;24:15347354241307038. doi: 10.1177/15347354241307038.
2
Oxidative Drugs and microRNA: New Opportunities for Cancer Prevention.氧化药物与微小RNA：癌症预防的新机遇
Cancers (Basel). 2022 Dec 26;15(1):132. doi: 10.3390/cancers15010132.

本文引用的文献

1
Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer.靶向内在凋亡途径：前列腺癌的一个机会窗口。
Cancers (Basel). 2021 Dec 23;14(1):51. doi: 10.3390/cancers14010051.
2
Olive Oil with Ozone-Modified Properties and Its Application.橄榄油的臭氧改性及其应用。
Molecules. 2021 May 21;26(11):3074. doi: 10.3390/molecules26113074.
3
Prevention of Covid-19 Infection and Related Complications by Ozonized Oils.臭氧油预防新冠病毒感染及相关并发症
J Pers Med. 2021 Mar 22;11(3):226. doi: 10.3390/jpm11030226.
4
Clinico-Pathological Importance of miR-146a in Lung Cancer.miR-146a在肺癌中的临床病理意义
Diagnostics (Basel). 2021 Feb 10;11(2):274. doi: 10.3390/diagnostics11020274.
5
The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival.线粒体脂肪氧化在癌细胞增殖和存活中的作用。
Cells. 2020 Dec 4;9(12):2600. doi: 10.3390/cells9122600.
6
ROS in cancer therapy: the bright side of the moon.ROS 在癌症治疗中的作用：月亮的光明面。
Exp Mol Med. 2020 Feb;52(2):192-203. doi: 10.1038/s12276-020-0384-2. Epub 2020 Feb 14.
7
MicroRNA Networks Modulate Oxidative Stress in Cancer.微小 RNA 网络调节癌症中的氧化应激。
Int J Mol Sci. 2019 Sep 11;20(18):4497. doi: 10.3390/ijms20184497.
8
Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation.神经母细胞瘤模型细胞系中的依托泊苷耐药与 13q14.3 单等位基因缺失和 miRNA-15a/16-1 下调有关。
Sci Rep. 2018 Sep 13;8(1):13762. doi: 10.1038/s41598-018-32195-7.
9
Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators.对癌症化疗药物的耐药性由关键的微小RNA调节因子决定。
Am J Cancer Res. 2017 Jun 1;7(6):1350-1371. eCollection 2017.
10
Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis.Nrf2 诱变激活驱动肝癌发生。
Cancer Res. 2017 Sep 15;77(18):4797-4808. doi: 10.1158/0008-5472.CAN-16-3538. Epub 2017 Jun 27.