Bailey C J, Flatt P R, Kwasowski P, Powell C J, Marks V
Acta Endocrinol (Copenh). 1986 Jun;112(2):224-9. doi: 10.1530/acta.0.1120224.
The effect of diet composition on plasma and intestinal concentrations of immunoreactive gastric inhibitory polypeptide (GIP) and intestinal K cell density was examined in obese hyperglycaemic (ob/ob) mice. The mice were reared from 3 to 11 weeks of age on either stock diet, a high fat (HF) cafeteria diet or a high carbohydrate (HC) cafeteria diet. The HF cafeteria diet increased the concentration of GIP in plasma (75%) and in the intestine (118%) and increased the density (54%) of GIP-secreting K cells in the upper jejunum compared with the stock diet. Plasma and intestinal GIP concentrations were not significantly altered by the HC cafeteria diet, although the density of K cells in the upper jejunum was increased (45%). The extent of hyperglycaemia and hyperinsulinaemia in ob/ob mice was not significantly altered by the HF and HC cafeteria diets. The results indicate that an increased amount of dietary fat chronically stimulates the production and secretion of GIP, and enhances intestinal K cell density in ob/ob mice.
研究了饮食组成对肥胖高血糖（ob/ob）小鼠血浆和肠道中免疫反应性胃抑制多肽（GIP）浓度以及肠道K细胞密度的影响。将小鼠从3周龄饲养至11周龄，分别给予常规饲料、高脂肪（HF）自助餐式饮食或高碳水化合物（HC）自助餐式饮食。与常规饲料相比，HF自助餐式饮食使血浆中GIP浓度升高了75%，肠道中升高了118%，并使空肠上段分泌GIP的K细胞密度增加了54%。HC自助餐式饮食虽未显著改变血浆和肠道GIP浓度，但空肠上段K细胞密度增加了45%。HF和HC自助餐式饮食对ob/ob小鼠高血糖和高胰岛素血症的程度无显著影响。结果表明，长期增加饮食脂肪量可刺激ob/ob小鼠GIP的产生和分泌，并提高肠道K细胞密度。
