Rejuvenating Fertility Center, 315 W 57th Street, Suite 208, New York, NY 10019, USA.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY 11219, USA.
Nutrients. 2022 Feb 24;14(5):966. doi: 10.3390/nu14050966.
Advanced glycation end products (AGEs), a heterogenous group of products formed by the reaction between protein and reducing sugars, can form endogenously due to non-enzymatic reactions or by exogenous sources such as diet where considerable increase in AGEs is observed due to the modification of food mainly by thermal processing. Recent studies have suggested that AGEs could impact, via inducing inflammation and oxidative stress, the reproductive health and fertility in both males and females. This review presents a summary of recently published data pertaining to the pathogenesis of dietary AGEs and their receptors as well as their potential impact on female reproductive health. More specifically, it will present data pertaining to dietary AGEs' involvement in the mechanistic pathogenesis of polycystic ovary syndrome, ovarian dysfunction, as well as the AGEs' effect perinatally on the female offspring reproduction. Understanding the mechanistic impact of dietary AGEs on female reproduction can help contribute to the development of targeted pharmacological therapies that will help curb rising female infertility.
糖基化终产物 (AGEs) 是蛋白质和还原糖之间反应形成的一组异质产物，可通过非酶反应内源性形成，也可通过饮食等外源性来源形成，饮食中由于食物的修饰（主要通过热加工），可观察到 AGEs 的大量增加。最近的研究表明，AGEs 可通过诱导炎症和氧化应激，影响男性和女性的生殖健康和生育能力。本综述总结了最近发表的关于饮食 AGEs 及其受体的发病机制以及它们对女性生殖健康潜在影响的相关数据。更具体地说，它将介绍与多囊卵巢综合征、卵巢功能障碍的发病机制以及 AGEs 对女性后代生殖的围产期影响有关的饮食 AGEs 数据。了解饮食 AGEs 对女性生殖的影响有助于开发靶向药理学疗法，有助于遏制女性不孕率的上升。
