Díaz-Barreda María Dolores, Sánchez-Marín Ignacio, Boned-Murillo Ana, Pérez-Navarro Itziar, Martínez Juana, Pardina-Claver Elena, Pérez Diana, Ascaso Francisco Javier, Ibáñez Juan
Department of Ophthalmology, Hospital Clínico Universitario Lozano Blesa, 50009 Zaragoza, Spain.
Department of Surgery, School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
J Clin Med. 2022 Feb 24;11(5):1216. doi: 10.3390/jcm11051216.
Changes in the cornea can influence outcomes in patients with primary open-angle glaucoma (POAG). We aimed to evaluate the relevance of changes in corneal biomechanics and intraocular pressure (IOP) in patients undergoing non-penetrating deep sclerectomy (NPDS) with the Esnoper V2000 implant (AJL Ophthalmic S.A., Gasteiz, Spain). We included 42 eyes of 42 patients with POAG scheduled for NPDS with the Esnoper V2000 implant. Biomechanical properties were measured by Ocular Response Analyzer G3 (ORA; Reichert Inc., Depew, NY, USA). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) were measured the day before surgery and on day 1, 7, and 30 and 2 and 3 months after surgery. CH initially increased, fell below the presurgical value at 30 days after the surgery, and increased again at 2 and 3 months. CRF, IOPcc, and IOPg decreased on the first day after surgery, then followed a trend of increasing but stayed below pre-surgery levels. All values reached statistical significance. While observed changes in corneal biomechanics after NPDS and Esnoper V2000 implant were significant, more studies are needed if we are to understand their influence on corneal biomechanics and their clinical relevance in POAG.
角膜的变化会影响原发性开角型青光眼（POAG）患者的治疗效果。我们旨在评估使用Esnoper V2000植入物（AJL Ophthalmic S.A.，西班牙加泰斯）进行非穿透性深层巩膜切除术（NPDS）的患者角膜生物力学和眼压（IOP）变化的相关性。我们纳入了42例计划使用Esnoper V2000植入物进行NPDS的POAG患者的42只眼睛。通过眼反应分析仪G3（ORA；美国纽约州迪皮尤的Reichert公司）测量生物力学特性。在手术前一天以及术后第1天、第7天、第30天以及术后2个月和3个月测量角膜滞后（CH）、角膜阻力因子（CRF）、角膜补偿眼压（IOPcc）和Goldmann相关眼压（IOPg）。CH最初升高，在术后30天降至术前值以下，并在2个月和3个月时再次升高。CRF、IOPcc和IOPg在术后第一天下降，然后呈上升趋势，但仍低于术前水平。所有值均具有统计学意义。虽然NPDS和Esnoper V2000植入术后观察到的角膜生物力学变化显著，但如果我们要了解它们对角膜生物力学的影响及其在POAG中的临床相关性，则需要更多的研究。
