Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, Poland.
Molecules. 2022 Feb 24;27(5):1534. doi: 10.3390/molecules27051534.
Parasitic diseases are still a huge problem for mankind. They are becoming the main cause of chronic diseases in the world. Migration of the population, pollution of the natural environment, and climate changes cause the rapid spread of diseases. Additionally, a growing resistance of parasites to drugs is observed. Many research groups are looking for effective antiparasitic drugs with low side effects. In this work, we present the current trends in the search for antiparasitic drugs. We report known drugs used in other disease entities with proven antiparasitic activity and research on new chemical structures that may be potential drugs in parasitic diseases. The described investigations of antiparasitic compounds can be helpful for further drug development.
寄生虫病仍然是人类的一个巨大问题。它们正成为世界范围内慢性病的主要病因。人口迁移、自然环境的污染以及气候变化导致疾病迅速传播。此外，寄生虫对药物的耐药性也在不断增加。许多研究小组正在寻找具有低副作用的有效抗寄生虫药物。在这项工作中，我们展示了寻找抗寄生虫药物的当前趋势。我们报告了已知在其他疾病实体中使用的具有已证实抗寄生虫活性的药物，以及对可能成为寄生虫病潜在药物的新化学结构的研究。所描述的抗寄生虫化合物的研究可能有助于进一步的药物开发。
