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基于聚氨酯的输尿管支架的表面功能化：构建抗菌涂层

Surface Functionalization of Ureteral Stents-Based Polyurethane: Engineering Antibacterial Coatings.

作者信息

Ecevit Kardelen, Silva Eduardo, Rodrigues Luísa C, Aroso Ivo, Barros Alexandre A, Silva Joana M, Reis Rui L

机构信息

3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal.

ICVS/3B's PT Government Associated Laboratory, 4805-017 Guimaraes, Portugal.

出版信息

Materials (Basel). 2022 Feb 23;15(5):1676. doi: 10.3390/ma15051676.

DOI:10.3390/ma15051676
PMID:35268903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8910958/
Abstract

Bacterial colonization of polyurethane (PU) ureteral stents usually leads to severe and challenging clinical complications. As such, there is an increasing demand for an effective response to this unmet medical challenge. In this study, we offer a strategy based on the functionalization of PU stents with chitosan-fatty acid (CS-FA) derivatives to prevent bacterial colonization. Three different fatty acids (FAs), namely stearic acid (SA), oleic acid (OA), and linoleic acid (LinA), were successfully grafted onto chitosan (CS) polymeric chains. Afterwards, CS-FA derivatives-based solutions were coated on the surface of PU stents. The biological performance of the modified PU stents was evaluated against the L929 cell line, confirming negligible cytotoxicity of the developed coating formulations. The antibacterial potential of coated PU stents was also evaluated against several microorganisms. The obtained data indicate that the base material already presents an adequate performance against , which slightly improved with the coating. However, the performance of the PU stents against Gram-negative bacteria was markedly increased with the surface functionalization approach herein used. As a result, this study reveals the potential use of CS-FA derivatives for surface functionalization of ureteral PU stents and allows for conjecture on its successful application in other biomedical devices.

摘要

聚氨酯（PU）输尿管支架的细菌定植通常会导致严重且具有挑战性的临床并发症。因此，对于有效应对这一未满足的医学挑战的需求日益增加。在本研究中，我们提供了一种基于用壳聚糖 - 脂肪酸（CS - FA）衍生物对PU支架进行功能化处理以防止细菌定植的策略。三种不同的脂肪酸（FAs），即硬脂酸（SA）、油酸（OA）和亚油酸（LinA），成功接枝到壳聚糖（CS）聚合物链上。之后，将基于CS - FA衍生物的溶液涂覆在PU支架表面。针对L929细胞系评估了改性PU支架的生物学性能，证实所开发的涂层配方的细胞毒性可忽略不计。还针对几种微生物评估了涂覆PU支架的抗菌潜力。所获得的数据表明，基材本身对 已经具有足够的性能，涂层使其略有改善。然而，通过本文使用的表面功能化方法，PU支架对革兰氏阴性菌的性能显著提高。因此，本研究揭示了CS - FA衍生物在输尿管PU支架表面功能化中的潜在用途，并使其有可能成功应用于其他生物医学设备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/b75819df7b4a/materials-15-01676-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/b75819df7b4a/materials-15-01676-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/082ec620ebb6/materials-15-01676-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/84fbbc465e76/materials-15-01676-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/af3bdb693c8f/materials-15-01676-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/bb6c5764d17e/materials-15-01676-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/e33df5364752/materials-15-01676-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/95f0159a335a/materials-15-01676-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/7d20ab41382e/materials-15-01676-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/9034af324155/materials-15-01676-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/b256a2ff8003/materials-15-01676-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8784/8910958/b75819df7b4a/materials-15-01676-g013.jpg

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