Department of Chemistry and Technologies of Drugs, Sapienza University of Rome , Rome, Italy.
Expert Opin Ther Pat. 2020 Dec;30(12):949-962. doi: 10.1080/13543776.2020.1853101.
: Antimicrobial resistance is a worldwide problem accounting for the reduction or in some cases absence of drugs effectiveness normally used in infections treatment. In the light of the even more spread ability of microbials to develop resistance, there is an urgent necessity to find novel and alternative routes to fight infections. Natural compounds or extracts can be a valid alternative either as monotherapy or as adjuvant in order to improve the effectiveness of the failing drugs. : This review provides a comprehensive update (2018-2020) on the development state of innovative antimicrobial agents based on natural compounds and extracts, also describing their compositions, methods of production and use, mechanism of action, along with anti-microbial data when available. : Owing to the pivotal role that natural compounds often cover in the finding of novel drugs, their in-depth analysis could pave the way to the discovery of new antimicrobial agents. Most of the alternative approaches reported in this short review were validated through and (animal as well as human) models. The employment of natural derived compounds and extracts, alone or in combination with classical antimicrobial drugs, as antimicrobial agents could represent an important achievement to challenge pathogens resistant mechanisms.
: 抗菌药物耐药性是一个全球性问题，导致通常用于治疗感染的药物的疗效降低，甚至在某些情况下失效。鉴于微生物更具传播能力，更易产生耐药性，因此迫切需要寻找新的替代方法来对抗感染。天然化合物或提取物无论是作为单一疗法还是作为辅助疗法，都可以作为有效的替代品，以提高现有失效药物的疗效。: 本综述提供了基于天然化合物和提取物的创新抗菌药物的最新发展情况（2018-2020 年），描述了它们的组成、生产和使用方法、作用机制，以及可用的抗菌数据。: 由于天然化合物在发现新型药物方面经常发挥关键作用，对它们的深入分析可能为发现新的抗菌药物铺平道路。本综述中报道的大多数替代方法都通过 和 （动物和人类）模型进行了验证。单独或与经典抗菌药物联合使用天然衍生化合物和提取物作为抗菌药物，可能是对抗病原体耐药机制的重要手段。
