Wong Pei-Chun, Song Sin-Mao, Tsai Pei-Hua, Maqnun Muhammad Jauharul, Wang Wei-Ru, Wu Jia-Lin, Jang Shian-Ching Jason
Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Department of Orthopedics, Taipei Medical University Hospital, Taipei 110301, Taiwan.
Materials (Basel). 2022 Mar 3;15(5):1887. doi: 10.3390/ma15051887.
In this study, a porous titanium zirconium (TiZr)-based bulk metallic foam was successfully fabricated using the Cu spacer by employing the hot press method. TiZr-based bulk metallic foams with porosities ranging from 0% to 50% were fabricated and analyzed. The results indicate that thermal conductivity increased with the addition of Cu spacer; the increased thermal conductivity reduced the holding time in the hot press method. Moreover, the compressive strength decreased from 1261 to 76 MPa when the porosity of the TiZr-based bulk metallic foam increased to 50%, and the compressive strength was predictable. In addition, the foam demonstrated favorable biocompatibility in cell viability, cell migration capacity, and calcium deposition tests. Moreover, the pore size of the porous TiZr-based bulk metallic foam was around 120 µm. In conclusion, TiZr-based bulk metallic foam has favorable biocompatibility, mechanical property controllability, and porous structure for bone ingrowth and subsequent enhanced osteointegration. This porous TiZr-based bulk metallic foam has great potential as an orthopedic implant to enhance bone healing and decrease healing time.
在本研究中，通过热压法使用铜间隔物成功制备了一种多孔钛锆（TiZr）基块状金属泡沫。制备并分析了孔隙率范围为0%至50%的TiZr基块状金属泡沫。结果表明，热导率随着铜间隔物的添加而增加；热导率的增加缩短了热压法中的保温时间。此外，当TiZr基块状金属泡沫的孔隙率增加到50%时，抗压强度从1261MPa降至76MPa，且抗压强度是可预测的。此外，该泡沫在细胞活力、细胞迁移能力和钙沉积测试中表现出良好的生物相容性。此外，多孔TiZr基块状金属泡沫的孔径约为120µm。总之，TiZr基块状金属泡沫具有良好的生物相容性、机械性能可控性以及利于骨长入和随后增强骨整合的多孔结构。这种多孔TiZr基块状金属泡沫作为一种骨科植入物具有巨大潜力，可促进骨愈合并缩短愈合时间。
