Institute of Materials Science and Engineering, National Central University, Taoyuan, Taiwan.
School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110783. doi: 10.1016/j.msec.2020.110783. Epub 2020 Feb 26.
Mg-based bulk metallic glass (BMG) and its composites have been promising candidates for orthopedic fixation implants because of their biocompatibility, low degradation rate, and osteogenic potential. However, the amorphous state is affected by the cooling rate during the casting process. Solid, unstable structures combined with amorphous and crystalline structures are generated when an insufficient cooling rate is used. Here, we aimed to design and synthesize a novel core-shell structure comprising an amorphous shell and a crystalline core in order to overcome the material size limit imposed by the cooling rate effects. Our results show that the core-shell structure of Mg-based BMG does have a lower degradation rate and can maintain a more amorphous structure after six weeks of degradation. Moreover, the biocompatibility and osteogenic effects were similar between the core-shell and solid structures of Mg-based BMG. In conclusion, the core-shell structure of Mg-based BMG exhibits a lower degradation rate while still enhancing osteogenic potential in vitro. This core-shell structure of Mg-based BMG overcomes the cooling rate effects and provides a new structure for manufacturing Mg-based BMG.
镁基块状金属玻璃（BMG）及其复合材料因其生物相容性、低降解率和成骨潜力而成为骨科固定植入物的有前途的候选材料。然而，非晶态会受到铸造过程中冷却速率的影响。当冷却速率不足时，会产生固体、不稳定的结构，以及非晶态和晶态结构的结合。在这里，我们旨在设计和合成一种新的核壳结构，包括非晶壳和结晶核，以克服冷却速率效应施加的材料尺寸限制。我们的结果表明，镁基 BMG 的核壳结构确实具有更低的降解率，并且在降解六周后仍能保持更非晶态的结构。此外，镁基 BMG 的核壳结构和固体结构之间的生物相容性和成骨效果相似。总之，镁基 BMG 的核壳结构表现出更低的降解率，同时在体外仍能增强成骨潜力。这种镁基 BMG 的核壳结构克服了冷却速率效应，并为制造镁基 BMG 提供了一种新的结构。
