Department of Neurobiology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Cells. 2022 Mar 4;11(5):889. doi: 10.3390/cells11050889.
Modulator of apoptosis protein1 (), also known as and , belongs to the PNMA gene family consisting of at least 15 genes located on different chromosomes. interacts with the BAX protein, one of the most important apoptosis regulators. Due to its critical role in a few of disease-associated pathways, is associated with many diseases such as cancers and neurological diseases. In this study, we introduced and its biological functions and reviewed the associations between and a few diseases including cancers, neurological diseases, and other diseases such as inflammation and heart diseases. We also explained possible biological mechanisms underlying the associations between and these diseases, and discussed a few future directions regarding , especially its potential roles in neurodegenerative disorders. In summary, plays a critical role in the development and progression of cancers and neurological diseases by regulating a few genes related to cellular apoptosis such as and and interacting with disease-associated miRNAs, including miR-25 and miR1228.
凋亡调节蛋白 1 ()，又称为 和 ，属于 PNMA 基因家族，该家族由至少 15 个位于不同染色体上的基因组成。与 BAX 蛋白相互作用，BAX 蛋白是最重要的凋亡调节蛋白之一。由于其在几种与疾病相关的途径中具有关键作用，与许多疾病相关，如癌症和神经退行性疾病。在本研究中，我们介绍了及其生物学功能，并回顾了与几种疾病（包括癌症、神经退行性疾病以及炎症和心脏病等其他疾病）之间的关联。我们还解释了 与这些疾病之间关联的潜在生物学机制，并讨论了关于 的几个未来方向，特别是其在神经退行性疾病中的潜在作用。总之，通过调节与细胞凋亡相关的几个基因（如 和 ）以及与疾病相关的 miRNAs（包括 miR-25 和 miR1228）相互作用，在癌症和神经退行性疾病的发生和发展中发挥关键作用。
Zotero 插件
