长链非编码RNA和微小RNA对肺癌细胞凋亡的影响

The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer.

作者信息

Ghafouri-Fard Soudeh, Aghabalazade Amin, Shoorei Hamed, Majidpoor Jamal, Taheri Mohammad, Mokhtari Majid

机构信息

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Pharmacology, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Front Oncol. 2021 Jul 21;11:714795. doi: 10.3389/fonc.2021.714795. eCollection 2021.

DOI:10.3389/fonc.2021.714795

PMID:34367998

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8335161/

Abstract

Apoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis different mechanisms. Lung cancer is among neoplastic conditions in which the role of non-coding RNAs in the regulation of apoptosis has been investigated. Non-coding RNAs that regulate apoptosis in lung cancer have functional interactions with PI3K/Akt, PTEN, GSK-3β, NF-κB, Bcl-2, Bax, p53, mTOR and other important cancer-related pathways. Globally, over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis of patients, while apoptosis-promoting ones have the opposite effect. In the current paper, we describe the impact of lncRNAs and miRNAs on cell apoptosis in lung cancer.

摘要

细胞凋亡是一种在多种生理情况下发生的协调细胞过程。细胞凋亡失调在许多病理情况下都有记录，尤其是在癌症中。非编码RNA通过不同机制调节细胞凋亡。肺癌是其中研究了非编码RNA在细胞凋亡调节中作用的肿瘤疾病之一。调节肺癌细胞凋亡的非编码RNA与PI3K/Akt、PTEN、GSK-3β、NF-κB、Bcl-2、Bax、p53、mTOR和其他重要的癌症相关通路存在功能相互作用。在全球范围内，抑制细胞凋亡的非编码RNA过表达与患者预后不良相关，而促进细胞凋亡的非编码RNA则有相反的作用。在本文中，我们描述了长链非编码RNA和微小RNA对肺癌细胞凋亡的影响。