Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea.
Department of Orthopedic Surgery, Ilsan Paik Hospital, Inje University, 170 Juhwa-ro, Ilsanseo-gu, Goyang-si 10380, Gyeonggi-do, Korea.
Int J Mol Sci. 2022 Feb 26;23(5):2583. doi: 10.3390/ijms23052583.
A large number of studies have focused on the role of substance P (SP) and the neurokinin-1 receptor (NK1R) in the pathogenesis of a variety of medical conditions. This review provides an overview of the role of the SP-NK1R pathway in the pathogenesis of musculoskeletal disorders and the evidence for its role as a therapeutic target for these disorders, which are major public health problems in most countries. To summarize, the brief involvement of SP may affect tendon healing in an acute injury setting. SP combined with an adequate conjugate can be a regenerative therapeutic option in osteoarthritis. The NK1R antagonist is a promising agent for tendinopathy, rheumatoid arthritis, and osteoarthritis. Research on the SP-NK1R pathway will be helpful for developing novel drugs for osteoporosis.
大量研究集中于 P 物质（SP）和神经激肽-1 受体（NK1R）在多种医学病症发病机制中的作用。本综述概述了 SP-NK1R 途径在肌肉骨骼疾病发病机制中的作用，以及其作为这些在大多数国家均为主要公共卫生问题的疾病的治疗靶点的证据。总之，SP 的短暂参与可能会影响急性损伤情况下的肌腱愈合。SP 与适当的结合物联合使用可能是骨关节炎的一种再生治疗选择。NK1R 拮抗剂是治疗肌腱病、类风湿关节炎和骨关节炎的有前途的药物。对 SP-NK1R 途径的研究将有助于开发骨质疏松症的新型药物。
