Jayanthi A, Tiwari D, Puzhankara L
Department of Periodontology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
J Indian Soc Periodontol. 2024 May-Jun;28(3):284-289. doi: 10.4103/jisp.jisp_56_24. Epub 2024 Dec 2.
Substance P (SP), a neuropeptide primarily released by neurons, has emerged as a key player in the intricate network of factors governing periodontal inflammation, immune responses, bone metabolism, and tissue regeneration. Due to its multifaceted role, it may be explored for its potential participation in periodontal therapeutic strategies. The databases, PubMed/MEDLINE, and SCOPUS were searched for all published articles on SP, its role in inflammation, and periodontal disease. The following search terms, adapted to the specific database, were used; "substance p AND periodontal *" AND "therapeutics" and records were retrieved. All articles not pertaining to SP in periodontal health and disease were excluded from the study. The full texts of eligible articles were retrieved. Data on SP and its role in inflammation and in periodontal health, disease, and therapy were extracted and have been presented as a narrative review. SP manifests during inflammatory phase of periodontal disease and is one of the causes of bone loss. According to studies, the gingival crevicular fluid from areas with active periodontal disease and bone loss had the greatest levels of SP. These chemicals may linger long enough to trigger neurogenic inflammation and elicit pain in tissues that are vulnerable to it. SP expression during progression of periodontal disease might be a risk factor for individuals with systemic inflammatory diseases, such as chronic arthritis. However, SP may be manipulated to provide avenues for management of periodontal disease and thereby serve as therapeutic target.
P物质（SP）是一种主要由神经元释放的神经肽，已成为调控牙周炎症、免疫反应、骨代谢和组织再生的复杂因素网络中的关键参与者。由于其具有多方面的作用，因此可探索其在牙周治疗策略中的潜在参与情况。在PubMed/MEDLINE和SCOPUS数据库中搜索了所有已发表的关于SP、其在炎症中的作用以及牙周疾病的文章。使用了根据特定数据库调整的以下搜索词：“P物质与牙周*”以及“治疗学”，并检索了记录。所有与牙周健康和疾病中SP无关的文章均被排除在研究之外。检索了符合条件的文章的全文。提取了关于SP及其在炎症以及牙周健康、疾病和治疗中的作用的数据，并以叙述性综述的形式呈现。SP在牙周疾病的炎症阶段表现出来，是骨质流失的原因之一。根据研究，来自患有活动性牙周疾病和骨质流失区域的龈沟液中SP水平最高。这些化学物质可能会停留足够长的时间来引发神经源性炎症，并在易受其影响的组织中引起疼痛。在牙周疾病进展过程中SP的表达可能是患有全身性炎症性疾病（如慢性关节炎）的个体的一个风险因素。然而，可以对SP进行调控，为牙周疾病的管理提供途径，从而作为治疗靶点。
