MTA-DE Public Health Research Group, University of Debrecen, 4032 Debrecen, Hungary.
Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Int J Mol Sci. 2022 Feb 28;23(5):2644. doi: 10.3390/ijms23052644.
Cytokine and chemokine receptors can promote tumor progression, invasion, and metastasis development by inducing different intracellular signaling pathways. The aim of this study was to determine the cytokine and chemokine receptor gene expression patterns in human melanoma cell lines. We found a large set of cytokine and chemokine receptor genes that were significantly differentially expressed between melanoma cell lines that originated from different subtypes of primary melanomas as well as cell lines that originated from melanoma metastases. The relative expressions of two receptor genes ( and ) were positively correlated with the invasive potential of the cell lines, whereas a negative correlation was observed for the gene expression. We also found a small set of receptor genes that exhibited a significantly decreased expression in association with a mutation. Based on our results, we assume that the analyzed cytokine and chemokine receptor collection may provide potential to distinguish the different subtypes of melanomas, helping us to understand the biological behavior of -mutated melanoma cells.
细胞因子和趋化因子受体可以通过诱导不同的细胞内信号通路来促进肿瘤的进展、侵袭和转移的发展。本研究的目的是确定人黑色素瘤细胞系中细胞因子和趋化因子受体基因的表达模式。我们发现了一大组细胞因子和趋化因子受体基因，这些基因在起源于不同原发性黑色素瘤亚型的黑色素瘤细胞系以及起源于黑色素瘤转移的细胞系之间存在显著的差异表达。两个受体基因（和）的相对表达与细胞系的侵袭潜能呈正相关，而基因的表达则呈负相关。我们还发现了一小部分受体基因与突变相关表达显著下调。基于我们的结果，我们假设分析的细胞因子和趋化因子受体集合可能有助于区分不同的黑色素瘤亚型，帮助我们了解突变型黑色素瘤细胞的生物学行为。
