Ventx 家族及其与 Nanog 的功能相似性：在胚胎发育和癌症进展中的作用。
Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression.
机构信息
School of Psychology and Neuroscience, University of St Andrews, St. Mary's Quad, South Street, St. Andrews KY16 9JP, UK.
Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Gangwon-Do, Korea.
出版信息
Int J Mol Sci. 2022 Mar 1;23(5):2741. doi: 10.3390/ijms23052741.
The Ventx family is one of the subfamilies of the ANTP () superfamily and belongs to the NK-like (NKL) subclass. Ventx is a homeobox transcription factor and has a DNA-interacting domain that is evolutionarily conserved throughout vertebrates. It has been extensively studied in , zebrafish, and humans. The Ventx family contains transcriptional repressors widely involved in embryonic development and tumorigenesis in vertebrates. Several studies have documented that the Ventx family inhibited dorsal mesodermal formation, neural induction, and head formation in and zebrafish. Moreover, Ventx2.2 showed functional similarities to Nanog and Barx1, leading to pluripotency and neural-crest migration in vertebrates. Among them, Ventx protein is an orthologue of the Ventx family in humans. Studies have demonstrated that human Ventx was strongly associated with myeloid-cell differentiation and acute myeloid leukemia. The therapeutic potential of Ventx family inhibition in combating cancer progression in humans is discussed. Additionally, we briefly discuss genome evolution, gene duplication, pseudo-allotetraploidy, and the homeobox family in .
Ventx 家族是 ANTP()超家族的一个亚家族，属于 NK 样（NKL）亚类。Ventx 是一种同源盒转录因子，具有 DNA 相互作用结构域，在整个脊椎动物中进化上是保守的。它在鸡胚、斑马鱼和人类中得到了广泛研究。Ventx 家族包含广泛参与脊椎动物胚胎发育和肿瘤发生的转录抑制剂。几项研究表明，Ventx 家族在鸡胚和斑马鱼中抑制背侧中胚层形成、神经诱导和头部形成。此外，Ventx2.2 与 Nanog 和 Barx1 表现出功能相似性，导致脊椎动物的多能性和神经嵴迁移。其中，Ventx 蛋白是人类 Ventx 家族的同源物。研究表明，人类 Ventx 与髓系细胞分化和急性髓系白血病密切相关。探讨了抑制 Ventx 家族在人类癌症进展中的治疗潜力。此外，我们还简要讨论了鸡胚中的基因组进化、基因复制、假四倍体和同源盒家族。
Zotero 插件