Boumpas D T, Mark G E, Tsokos G C
Anticancer Res. 1986 May-Jun;6(3 Pt B):491-7.
Vertebrate cells harbor genes (proto-oncogenes) which carry the potential to become dominant transforming genes or oncogenes. Evolutionary conservation is the hallmark of these genes which implies that they have a major role in the growth and differentiation of the cells. In vitro activation of various cell types (immune cells, fibroblasts, etc.) leads to increased expression of various oncogenes in a certain temporal sequential order. Lymphoid cells from mice with autoimmune disorders have been shown to exhibit increased oncogene expression. Mononuclear cells from patients with angioimmunoblastic lymphadenopathy and certain autoimmune disorders (systemic lupus erythematosus and rheumatoid arthritis) express increased quantities of certain oncogenes. In this review, we discuss the role of oncogenes in the activation of immune cells and the pathogenesis of human autoimmunity.
脊椎动物细胞含有一些基因（原癌基因），这些基因具有成为显性转化基因或癌基因的潜力。这些基因的标志是进化保守性，这意味着它们在细胞的生长和分化中起主要作用。体外激活各种细胞类型（免疫细胞、成纤维细胞等）会导致各种癌基因按一定的时间顺序增加表达。已证明患有自身免疫性疾病的小鼠的淋巴细胞表现出癌基因表达增加。血管免疫母细胞性淋巴结病和某些自身免疫性疾病（系统性红斑狼疮和类风湿性关节炎）患者的单核细胞表达某些癌基因的量增加。在这篇综述中，我们讨论癌基因在免疫细胞激活和人类自身免疫性疾病发病机制中的作用。
