Boumpas D T, Eleftheriades E G, Barez S, Tsokos G C
Kidney Disease Section, National Institutes of Diabetes, Digestive and Kidney Disease, Bethesda, Maryland 20892.
Anticancer Res. 1988 Sep-Oct;8(5A):977-84.
The discovery of oncogenes has offered new insights into the physiology of lymphocytes. Proto-oncogenes encode proteins that are associated with the control of lymphocyte activation, proliferation and differentiation. Mononuclear cells from patients and animals with autoimmune disorders express increased quantities of oncogenes such as c-myc, c-myb and c-raf. In this review we discuss some of the cellular and molecular events associated with lymphocyte activation and the role that the oncogenes play in each of these events. The regulation of the expression of oncogenes in these cells is also reviewed. Finally, the role of the increased oncogene expression in the pathogenesis of autoimmune diseases is discussed.
癌基因的发现为淋巴细胞生理学提供了新的见解。原癌基因编码的蛋白质与淋巴细胞的激活、增殖和分化控制相关。来自患有自身免疫性疾病的患者和动物的单核细胞表达增加量的癌基因，如c-myc、c-myb和c-raf。在本综述中，我们讨论了一些与淋巴细胞激活相关的细胞和分子事件，以及癌基因在这些事件中所起的作用。还综述了这些细胞中癌基因表达的调控。最后，讨论了癌基因表达增加在自身免疫性疾病发病机制中的作用。
