School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Division of Metabolism and Endocrinology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
Int J Environ Res Public Health. 2022 Mar 5;19(5):3062. doi: 10.3390/ijerph19053062.
Adiponectin has anti-inflammatory activity against atherosclerosis. Aortic stiffness is a common manifestation of atherosclerosis in diabetes mellitus and elderly persons. This study aimed to evaluate whether low serum adiponectin levels were associated with aortic stiffness in geriatric diabetic patients. Blood samples were obtained from 130 diabetic participants aged ≥ 65 years. We defined high aortic stiffness based on a carotid−femoral pulse wave velocity (cfPWV) of >10 m/s. Circulating adiponectin concentrations were examined using enzyme-linked immunosorbent assays. Sixty-six participants (50.8%) had aortic stiffness. Patients with aortic stiffness had lower serum adiponectin concentrations than those in the control group (p < 0.001). Multivariate logistic regression analysis showed that the adiponectin level (odds ratio: 0.939, 95% confidence interval: 0.898−0.981, p = 0.005) was an independent predictor of aortic stiffness in elderly diabetic persons. Multivariate forward stepwise linear regression analysis also demonstrated that the adiponectin level (β = −0.256, adjusted R2 change = 0.100, p = 0.003) was negatively associated with cfPWV values in older diabetic patients. In conclusion, serum adiponectin is negatively correlated with cfPWV and is an independent predictor of aortic stiffness in elderly diabetic persons.
脂联素具有抗炎活性，可对抗动脉粥样硬化。主动脉僵硬度是糖尿病和老年人中动脉粥样硬化的常见表现。本研究旨在评估老年糖尿病患者血清脂联素水平是否与主动脉僵硬度相关。从 130 名年龄≥65 岁的糖尿病患者中采集血样。我们根据颈股脉搏波速度（cfPWV）>10 m/s 来定义高主动脉僵硬度。使用酶联免疫吸附试验检测循环脂联素浓度。66 名患者（50.8%）存在主动脉僵硬度。与对照组相比，僵硬度组的血清脂联素浓度较低（p<0.001）。多变量逻辑回归分析表明，脂联素水平（比值比：0.939，95%置信区间：0.898-0.981，p=0.005）是老年糖尿病患者主动脉僵硬度的独立预测因子。多元逐步线性回归分析还表明，脂联素水平（β=-0.256，调整 R2 变化=0.100，p=0.003）与老年糖尿病患者的 cfPWV 值呈负相关。总之，血清脂联素与 cfPWV 呈负相关，是老年糖尿病患者主动脉僵硬度的独立预测因子。
