Division of Environmental Health and Occupational Medicine, Department of Population Health, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345 Wroclaw, Poland.
Department of Rheumatology and Internal Medicine, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland.
Int J Environ Res Public Health. 2022 Mar 6;19(5):3099. doi: 10.3390/ijerph19053099.
The purpose of this study was to determine the relationship between cadmium exposure and the likelihood of developing or exacerbating symptoms of inflammatory arthritis (IA). The study included 51 IA patients and 46 control subjects. Demographic and lifestyle data were collected. Haematological and biochemical parameters and blood cadmium levels (Cd-B) were determined. Cd-B correlated positively with age, smoking, living in a high-traffic area, and serum levels of inflammatory markers and negatively with mean corpuscular haemoglobin concentration (MCHC). The binary logistic regression model implied that high Cd-B (≥0.65 μg/L) is linked with an increased risk of IA in the studied population (odds ratio: 4.4). High levels of DNA oxidative damage marker (8-hydroxy-2'-deoxyguanosine) (≥7.66 ng/mL) and cyclooxygenase-2 (≥22.9 ng/mL) and frequent consumption of offal was also associated with increased risk of IA. High Cd-B was related to increased risk of disease symptoms onset in the group of IA patients, decreased the level of interleukin 10, and positively correlated with the disease activity. Increased Cd-B is associated with intensified inflammatory processes and decreased haemoglobin levels; in IA patients with decreased anti-inflammatory interleukin 10. These changes partly explain why cadmium exposure and a high cadmium body burden may raise the risk of IA and of disease symptoms exacerbation.
本研究旨在探讨镉暴露与炎症性关节炎（IA）发病或加重症状的关系。研究纳入 51 例 IA 患者和 46 例对照者，收集人口统计学和生活方式数据，检测血液学和生化参数以及血镉水平（Cd-B）。Cd-B 与年龄、吸烟、居住在交通繁忙地区以及血清炎症标志物水平呈正相关，与平均红细胞血红蛋白浓度（MCHC）呈负相关。二元逻辑回归模型提示，高 Cd-B（≥0.65μg/L）与研究人群中 IA 风险增加相关（比值比：4.4）。高水平的 DNA 氧化损伤标志物（8-羟基-2'-脱氧鸟苷）（≥7.66ng/ml）和环氧化酶-2（≥22.9ng/ml）以及经常食用动物内脏也与 IA 风险增加相关。高 Cd-B 与 IA 患者疾病症状发作风险增加相关，降低白细胞介素 10 水平，并与疾病活动度呈正相关。Cd-B 升高与炎症过程加剧和血红蛋白水平降低有关；在白细胞介素 10 抗炎作用降低的 IA 患者中更是如此。这些变化部分解释了为什么镉暴露和体内镉负荷增加可能会增加 IA 以及疾病症状恶化的风险。
