Immunotoxicology group, Department of Ecology, Institute for Biological Research "Siniša Stanković"- National Institute of Republic of Serbia, University of Belgrade, 142 Bulevar despota Stefana, Belgrade 11000, Serbia.
Immunotoxicology group, Department of Ecology, Institute for Biological Research "Siniša Stanković"- National Institute of Republic of Serbia, University of Belgrade, 142 Bulevar despota Stefana, Belgrade 11000, Serbia; Université Côte d'Azur, Institute of Biology Valrose, Nice (iBV), INSERM U1091, 06107 Nice, France.
Immunol Lett. 2021 Dec;240:106-122. doi: 10.1016/j.imlet.2021.10.003. Epub 2021 Oct 21.
Cadmium (Cd) represents a unique hazard because of the long biological half-life in humans (20-30 years). This metal accumulates in organs causing a continuum of responses, with organ disease/failure as extreme outcome. Some of the cellular and molecular alterations in target tissues can be related to immune-modulating potential of Cd. This metal may cause adverse responses in which components of the immune system function as both mediators and effectors of Cd tissue toxicity, which, in combination with Cd-induced alterations in homeostatic reparative activities may contribute to tissue dysfunction. In this work, current knowledge concerning inflammatory/autoimmune disease manifestations found to be related with cadmium exposure are summarized. Along with epidemiological evidence, animal and in vitro data are presented, with focus on cellular and molecular immune mechanisms potentially relevant for the disease susceptibility, disease promotion, or facilitating development of pre-existing pathologies.
镉 (Cd) 因其在人体内的生物半衰期长（20-30 年）而成为一种独特的危害物。这种金属在器官中积累，导致一系列的反应，以器官疾病/衰竭为极端后果。靶组织中的一些细胞和分子改变可能与 Cd 的免疫调节潜力有关。这种金属可能会引起不良反应，其中免疫系统的成分既作为 Cd 组织毒性的介质，也作为效应物发挥作用，这与 Cd 诱导的内稳态修复活动的改变相结合，可能导致组织功能障碍。在这项工作中，总结了目前关于与镉暴露有关的炎症/自身免疫性疾病表现的知识。除了流行病学证据外，还介绍了动物和体外数据，重点关注与疾病易感性、疾病促进或促进现有病理发展相关的潜在细胞和分子免疫机制。
