Kazemi Tayebeh, Hashemi Seyed Basir, Keshavarz Najmeh, Monshizadeh Leila, Kaboodkhani Reza, Babaei Amirhossein
Department of Otolaryngology Head and Neck Surgery, Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Otolaryngology Head and Neck Surgery, Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Pediatr Otorhinolaryngol. 2022 May;156:111041. doi: 10.1016/j.ijporl.2022.111041. Epub 2022 Jan 7.
This study aims to identify the auditory, speech, and surgical outcomes of cochlear implantation in patients with profound SNHL following bacterial meningitis.
Subjects with bilateral severe to profound SNHL who underwent unilateral cochlear implantation from 2003 to 2020 were included in this historical cohort study. The main outcomes were assessed using Categories of Auditory Performance (CAP) and Speech Intelligibility Ratings (SIR) scores. The CAP and SIR outcomes were collected as three-time points after surgery: 6, 12, and 24 months. In order to achieve the strength of the relationship and for computing the Risk Ratio (RR) by log-binominal regression method, we used two binary categorizations of CAP and SIR in our analyses.
The mean of age at implantation of the study and control group were 144.30 (156.90) and 121.10 (133.70) months, respectively. In the study group, 19 of 35 (54.3%) patients were male, and 16 (45.7%) were female. In the control group, 34 of 81 (42.0%) patients were male and 47 (58.0%) were female. The mean scores of CAP and SIR in our study improved significantly during the time in both groups. All p-values (p) were significant in both groups (T2 vs T1, T3 vs T1, and T3 vs T2). Our analysis by log-binomial regression and computing the RR based on the first and second categorization of CAP and SIR showed moderate to strong relationships between the presence of a history of meningitis and inappropriate CAP and SIR outcomes in these patients.
Although subjects who were deafened due to meningitis benefit significantly from cochlear implantation, we found moderate to strong relationships between the history of meningitis and inappropriate CAP and SIR outcomes in these patients.
本研究旨在确定细菌性脑膜炎后重度感音神经性听力损失（SNHL）患者人工耳蜗植入的听觉、言语和手术效果。
本历史性队列研究纳入了2003年至2020年期间接受单侧人工耳蜗植入的双侧重度至极重度SNHL患者。主要结局采用听觉表现类别（CAP）和言语可懂度评分（SIR）进行评估。CAP和SIR结局在术后6个月、12个月和24个月这三个时间点收集。为了确定关系强度并通过对数二项回归法计算风险比（RR），我们在分析中对CAP和SIR采用了两种二元分类。
研究组和对照组的植入时平均年龄分别为144.30（156.90）个月和121.10（133.70）个月。研究组中，35名患者中有19名（54.3%）为男性，16名（45.7%）为女性。对照组中，81名患者中有34名（42.0%）为男性，47名（58.0%）为女性。在两组中，我们研究的CAP和SIR平均评分在这段时间内均显著改善。两组中所有p值（p）均具有显著性（T2与T1、T3与T1以及T3与T2）。我们通过对数二项回归分析并基于CAP和SIR的首次和第二次分类计算RR，结果显示脑膜炎病史与这些患者不适当的CAP和SIR结局之间存在中度至强相关性。
尽管因脑膜炎致聋的患者从人工耳蜗植入中显著获益，但我们发现脑膜炎病史与这些患者不适当的CAP和SIR结局之间存在中度至强相关性。
