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Purification of human plasma inactive renin by immunoaffinity chromatography on profragment-specific IgG.

作者信息

Kim S J, Hirose S, Murakami K

出版信息

Biochim Biophys Acta. 1986 Sep 5;873(1):27-30. doi: 10.1016/0167-4838(86)90185-8.

DOI:10.1016/0167-4838(86)90185-8
PMID:3527274
Abstract

Inactive renin was purified to apparent homogeneity from human plasma by ion exchange, gel filtration, Affi-Gel blue, immunoaffinity chromatography on profragment-specific IgG coupled to Sepharose, and preparative HPLC. By this method, a 460000-fold purification was obtained. The purified renin was totally inactive and was activated by trypsin.

摘要

相似文献

1
Purification of human plasma inactive renin by immunoaffinity chromatography on profragment-specific IgG.
Biochim Biophys Acta. 1986 Sep 5;873(1):27-30. doi: 10.1016/0167-4838(86)90185-8.
2
Application of immunochemical methods to the identification and characterization of rat kidney inactive renin.免疫化学方法在大鼠肾脏无活性肾素鉴定及特性研究中的应用
Hypertension. 1985 Mar-Apr;7(2):236-43. doi: 10.1161/01.hyp.7.2.236.
3
Isolation and activation of inactive renin from human kidney and plasma. Plasma and renal inactive renins have different molecular weights.从人肾脏和血浆中分离并激活无活性肾素。血浆和肾脏中的无活性肾素具有不同的分子量。
Hypertension. 1981 Sep-Oct;3(5):509-15. doi: 10.1161/01.hyp.3.5.509.
4
Immunological evidence that kidney is primary source of circulating inactive prorenin in rats.肾脏是大鼠循环中无活性肾素原主要来源的免疫学证据。
Am J Physiol. 1991 Apr;260(4 Pt 1):E526-36. doi: 10.1152/ajpendo.1991.260.4.E526.
5
Detection and isolation of inactive, large molecular weight renin in human kidney and plasma.人肾和血浆中无活性大分子肾素的检测与分离。
Hypertension. 1981 May-Jun;3(3 Pt 2):I30-40. doi: 10.1161/01.hyp.3.3_pt_2.i30.
6
Biochemical similarity of partially purified inactive renins from human plasma and kidney.来自人血浆和肾脏的部分纯化的无活性肾素的生化相似性。
Hypertension. 1982 May-Jun;4(3 Pt 2):86-95.
7
Human plasma inactive renin: purification and activation by proteases.人血浆无活性肾素：蛋白酶的纯化与激活
J Clin Endocrinol Metab. 1982 Oct;55(4):619-27. doi: 10.1210/jcem-55-4-619.
8
The purification of a high-molecular-weight, enzymatically inactive renin precursor from human kidney.从人肾中纯化一种高分子量、无酶活性的肾素前体。
J Hypertens. 1984 Jun;2(3):305-10.
9
Partial purification of human renin.人肾素的部分纯化
Circ Res. 1977 Oct;41(4 Suppl 2):4-7. doi: 10.1161/01.res.41.4.4.
10
Immunoaffinity chromatography of canine high-molecular-weight renin: partial purification and characterization.犬高分子量肾素的免疫亲和层析：部分纯化及特性鉴定
Clin Sci (Lond). 1983 Aug;65(2):117-20. doi: 10.1042/cs0650117.

引用本文的文献

1
Similarity between physicochemical properties of recombinant rat prorenin and native inactive renin.重组大鼠肾素原与天然无活性肾素的理化性质相似性。
Biochem J. 1991 May 1;275 ( Pt 3)(Pt 3):727-31. doi: 10.1042/bj2750727.