Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Midori-Ku, Yokohama, Japan.
Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Midori-Ku, Yokohama, Japan.
Ultrasound Med Biol. 2022 May;48(5):933-944. doi: 10.1016/j.ultrasmedbio.2022.01.021. Epub 2022 Mar 7.
Ultrasound facilitates the penetration of macromolecular compounds through the skin and offers a promising non-invasive technique for transdermal delivery. However, technical difficulties in quantifying ultrasound-related parameters have restricted further analysis of the sonophoresis mechanism. In this study, we devise a bolt-clamped Langevin transducer-based sonophoresis device that enables us to measure with a thin lead zirconate titanate (PZT) sensor. One-dimensional acoustic theory accounting for wave interaction at the skin interface indicates that the acoustic pressure and cavitation onset on the skin during sonophoresis are sensitive to the subcutaneous support, meaning that there is a strong need to perform the pressure measurement in an experimental environment replacing the human body. From a series of the experiments with our new device, the transdermal penetration of polystyrene, silica and gold nanoparticles is found to depend on the size and material of the particles, as well as the hardness of the subcutaneous support material. We speculate from the acoustic pressure measurement that the particles' penetration results from the mechanical action of cavitation.
超声能促进大分子化合物穿透皮肤，为经皮给药提供了一种很有前途的非侵入性技术。然而，在定量超声相关参数方面存在技术困难，限制了声透技术机制的进一步分析。在本研究中，我们设计了一种基于螺栓夹紧的兰杰文换能器的声透设备，该设备使我们能够使用薄的锆钛酸铅（PZT）传感器进行测量。考虑到皮肤界面处波相互作用的一维声学理论表明，声透过程中皮肤处的声压和空化起始对皮下支撑物很敏感，这意味着在实验环境中进行压力测量以替代人体具有很强的必要性。从我们的新设备进行的一系列实验中发现，聚苯乙烯、二氧化硅和金纳米粒子的经皮渗透取决于粒子的大小和材料，以及皮下支撑材料的硬度。我们从声压测量推测，粒子的渗透是由空化的机械作用引起的。
