Media Lab, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Adv Mater. 2023 Jun;35(23):e2300066. doi: 10.1002/adma.202300066. Epub 2023 Apr 19.
Increased consumer interest in healthy-looking skin demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. Here, a conformable ultrasound patch (cUSP) that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis in the fluid coupling medium between the patch and the skin is reported. The cUSP consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets (0.8 cm , 1 mm deep) over larger areas of conformal contact (20 cm ). Multiphysics simulation models, acoustic spectrum analysis, and high-speed videography are used to characterize transducer deflection, acoustic pressure fields, and resulting cavitation bubble dynamics in the coupling medium. The final system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro with a 10 min ultrasound application, demonstrating the suitability of the device for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.
消费者对健康肌肤的兴趣日益浓厚，这就需要一种安全有效的方法来增加创新型治疗性化妆品的经皮吸收。然而，小分子药物的渗透受到角质层固有屏障功能的限制。在这里，报道了一种顺应性超声贴（cUSP），它通过在贴剂和皮肤之间的流体耦合介质中产生中频声流，增强了烟酰胺的经皮传递。cUSP 由嵌入在软弹性体中的压电换能器组成，在更大的顺应性接触面积（20cm）上产生局部空化口袋（0.8cm，1mm 深）。多物理场模拟模型、声谱分析和高速录像用于描述换能器的挠度、声场和耦合介质中产生的空化气泡动力学。最终系统在猪模型体外展示了 26.2 倍的烟酰胺传递增强，在 10 分钟的超声应用中，证明了该设备适合于患有皮肤疾病和皮肤过早老化的患者和消费者进行短时间暴露、大面积声流应用。
