Department of Pneumology, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
NPJ Prim Care Respir Med. 2022 Mar 10;32(1):11. doi: 10.1038/s41533-022-00270-2.
The aim of this observational, retrospective study was to describe characteristics, treatment patterns, and adherence among patients with asthma who initiated multiple-inhaler triple therapy (MITT) in Catalonia, Spain. This study used data of patients initiating MITT in 2016 from the SIDIAP (Information System for Research in Primary Care) database, which covers ~80% of the Catalonian population (5.8 million). Of 1,204 patients initiating MITT, 361 (30.0%) stepped down (discontinued ≥ 1 and continued ≥1 MITT component) and 89 (7.4%) stopped all three components of MITT for a period of 60 days during the following 12 months. In the follow-up period, 196 (16.3%) patients were considered adherent to MITT (>0.8 proportion of days covered [PDC]), with a mean (standard deviation) PDC of 0.52 (0.51) days. Given the low adherence and substantial rates of step down/discontinuation among patients initiating MITT, there is an urgent need to implement strategies to improve treatment adherence/persistence.
本观察性、回顾性研究旨在描述在西班牙加泰罗尼亚地区起始三联多吸入器疗法（MITT）的哮喘患者的特征、治疗模式和依从性。本研究使用了来自 SIDIAP（初级保健研究信息系统）数据库的 2016 年起始 MITT 的患者数据，该数据库覆盖了加泰罗尼亚约 80%的人口（580 万）。在起始 MITT 的 1204 名患者中，有 361 名（30.0%）减少了剂量（至少停止使用 1 种和继续使用 ≥1 种 MITT 成分），有 89 名（7.4%）在接下来的 12 个月中停止使用 MITT 的所有 3 种成分 60 天。在随访期间，196 名（16.3%）患者被认为对 MITT 具有依从性（>0.8 比例的治疗天数覆盖[PDC]），平均（标准差）PDC 为 0.52（0.51）天。鉴于起始 MITT 的患者的依从性低且停药/减药率较高，迫切需要实施策略来提高治疗的依从性/持久性。
