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促黄体生成激素释放因子在人胎盘中的定位

Localization of luteinizing hormone-releasing factor in the human placenta.

作者信息

Khodr G S, Siler-Khodr T

出版信息

Fertil Steril. 1978 May;29(5):523-6. doi: 10.1016/s0015-0282(16)43277-2.

DOI:10.1016/s0015-0282(16)43277-2
PMID:352732
Abstract

Luteinizing hormone-releasing factor (LRF) has been found to be produced by the placenta. In the present study, the localization of this releasing factor was delineated by the use of an immunofluorescnece technique. Intense fluorescence was localized in the cytotrophoblast, along the outer surface layer of the syncytiotrophoblast, and in the villous stroma. The cytoplasm of the syncytiotrophoblast did not exhibit any fluorescence. It may be speculated that placental LRF plays a role in regulating the production of human chorionic gonadotropin.

摘要

已发现胎盘可产生促黄体生成素释放因子(LRF)。在本研究中,运用免疫荧光技术描绘了这种释放因子的定位。强烈荧光定位于细胞滋养层、合体滋养层外表面层以及绒毛间质。合体滋养层的细胞质未显示任何荧光。可以推测,胎盘LRF在调节人绒毛膜促性腺激素的产生中发挥作用。

相似文献

1
Localization of luteinizing hormone-releasing factor in the human placenta.促黄体生成激素释放因子在人胎盘中的定位
Fertil Steril. 1978 May;29(5):523-6. doi: 10.1016/s0015-0282(16)43277-2.
2
Immunohistochemical demonstration of luteinizing hormone-releasing factor-like material in human syncytiotrophoblast and trophoblastic tumours.人合体滋养层细胞和滋养层肿瘤中促黄体生成激素释放因子样物质的免疫组织化学显示
Clin Endocrinol (Oxf). 1980 May;12(5):441-51. doi: 10.1111/j.1365-2265.1980.tb02734.x.
3
Changes in luteinizing hormone-releasing hormone in human placenta throughout pregnancy.整个孕期人胎盘中促黄体生成激素释放激素的变化。
Obstet Gynecol. 1982 Oct;60(4):444-9.
4
A novel change in cytologic localization of human chorionic gonadotropin and human placental lactogen in first-trimester placenta in the course of gestation.妊娠过程中孕早期胎盘人绒毛膜促性腺激素和人胎盘催乳素细胞定位的一种新变化。
Am J Obstet Gynecol. 1992 Jul;167(1):217-22. doi: 10.1016/s0002-9378(11)91661-5.
5
The effect of luteinizing hormone-releasing factor on human chorionic gonadotropin secretion.促黄体生成素释放因子对人绒毛膜促性腺激素分泌的影响。
Fertil Steril. 1978 Sep;30(3):301-4. doi: 10.1016/s0015-0282(16)43516-8.
6
Extrahypothalamic luteinizing hormone-releasing factor (LRF): release of immunoreactive LRF in vitro.下丘脑外促黄体生成激素释放因子(LRF):体外免疫反应性LRF的释放
Fertil Steril. 1979 Sep;32(3):294-6. doi: 10.1016/s0015-0282(16)44236-6.
7
Expression of human gonadotropin-releasing hormone receptor gene in the placenta and its functional relationship to human chorionic gonadotropin secretion.人促性腺激素释放激素受体基因在胎盘中的表达及其与绒毛膜促性腺激素分泌的功能关系。
J Clin Endocrinol Metab. 1995 Feb;80(2):580-5. doi: 10.1210/jcem.80.2.7852524.
8
Content of luteinizing hormone-releasing factor in the human placenta.人胎盘中促黄体生成激素释放因子的含量
Am J Obstet Gynecol. 1978 Jan 15;130(2):216-9. doi: 10.1016/0002-9378(78)90369-1.
9
Presence of immunoreactive luteinizing hormone-releasing factor in hydatidiform mole as compared with normal human trophoblastic tissue.
Placenta Suppl. 1981;3:257-61.
10
[Trophoblast: its functional regulation and pathophysiological profiles].[滋养层细胞:其功能调节与病理生理特征]
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Aug;44(8):918-28.

引用本文的文献

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Cell Mol Biol Lett. 2017 Aug 9;22:15. doi: 10.1186/s11658-017-0046-0. eCollection 2017.
2
Neuroendocrineimmunology (NEI) at the turn of the century: towards a molecular understanding of basic mechanisms and implications for reproductive physiopathology.世纪之交的神经内分泌免疫学(NEI):迈向对基本机制的分子理解及其对生殖生理病理学的影响。
Endocrine. 1995 Dec;3(12):845-61. doi: 10.1007/BF02738890.
3
Differential expression of gonadotropin-releasing hormone (GnRH) in pancreas during rat pregnancy.
在大鼠妊娠期间,促性腺激素释放激素(GnRH)在胰腺中的差异表达。
Endocrine. 2009 Dec;36(3):538-45. doi: 10.1007/s12020-009-9264-1. Epub 2009 Oct 24.
4
Presence of immunoreactive gonadotropin releasing hormone (GnRH) and its receptor (GnRHR) in rat ovary during pregnancy.孕期大鼠卵巢中免疫反应性促性腺激素释放激素(GnRH)及其受体(GnRHR)的存在。
Mol Reprod Dev. 2008 Jun;75(6):1031-44. doi: 10.1002/mrd.20834.
5
Nucleotide sequence analyses predict that human pituitary and human placental gonadotropin-releasing hormone receptors have identical primary structures.核苷酸序列分析预测,人类垂体和人类胎盘促性腺激素释放激素受体具有相同的一级结构。
Endocrine. 1998 Dec;9(3):281-7. doi: 10.1385/ENDO:9:3:281.
6
Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants.AT1受体mRNA和蛋白在正常胎盘的细胞定位及其在宫内生长受限中的表达降低。血管紧张素II刺激血管舒张剂的释放。
J Clin Invest. 1998 Jan 15;101(2):442-54. doi: 10.1172/JCI119881.
7
Placental progonadotropin-releasing hormone (pro-GnRH) in the rhesus monkey.恒河猴胎盘促性腺激素释放激素(前促性腺激素释放激素)
Endocrine. 1997 Feb;6(1):21-4. doi: 10.1007/BF02738797.
8
Gene expression of gonadotropin-releasing hormone in early pregnant rat and steroid hormone exposed mouse uteri.早期妊娠大鼠和暴露于类固醇激素的小鼠子宫中促性腺激素释放激素的基因表达。
J Endocrinol Invest. 1996 Dec;19(11):708-13. doi: 10.1007/BF03347872.
9
GnRH in pregnancy.孕期促性腺激素释放激素
Arch Gynecol Obstet. 1996;259(1):1-6. doi: 10.1007/BF02505301.
10
Morphologic and cytochemical identification of microperoxisomes in human and non-human primate placental trophoblast.人类和非人类灵长类胎盘滋养层中微小过氧化物酶体的形态学和细胞化学鉴定
Histochemistry. 1982;74(1):115-21. doi: 10.1007/BF00495057.