Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea.
Sci Rep. 2022 Mar 10;12(1):3885. doi: 10.1038/s41598-022-07586-6.
The acute stress response is a natural and fundamental reaction that balances the physiological conditions of the brain. To maintain homeostasis in the brain, the response is based on changes over time in hormones and neurotransmitters, which are related to resilience and can adapt successfully to acute stress. This increases the need for dynamic analysis over time, and new approaches to examine the relationship between metabolites have emerged. This study investigates whether the constructed metabolic network is a realistic or a random network and is affected by acute stress. While the metabolic network in the control group met the criteria for small-worldness at all time points, the metabolic network in the stress group did not at some time points, and the small-worldness had resilience after the fifth time point. The backbone metabolic network only met the criteria for small-worldness in the control group. Additionally, creatine had lower local efficiency in the stress group than the control group, and for the backbone metabolic network, creatine and glutamate were lower and higher in the stress group than the control group, respectively. These findings provide evidence of metabolic imbalance that may be a pre-stage of alterations to brain structure due to acute stress.
急性应激反应是一种自然而基本的反应，它平衡着大脑的生理状态。为了在大脑中保持体内平衡，这种反应基于激素和神经递质随时间的变化，这些变化与韧性有关，可以成功适应急性应激。这增加了对随时间变化的动态分析的需求，并且出现了新的方法来检查代谢物之间的关系。本研究探讨了构建的代谢网络是真实的还是随机的网络，以及是否受到急性应激的影响。虽然对照组的代谢网络在所有时间点都符合小世界的标准，但应激组的代谢网络在某些时间点不符合标准，并且在第五个时间点后具有恢复力。骨干代谢网络仅在对照组中符合小世界的标准。此外，在应激组中肌酸的局部效率低于对照组，而对于骨干代谢网络，应激组中肌酸和谷氨酸的水平分别低于和高于对照组。这些发现提供了代谢失衡的证据，这可能是由于急性应激导致大脑结构改变的前阶段。
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