Department of Neuroscience, ERN Neuromuscular Center, University of Padova, via Giustiniani, 5, 35128, Padua, Italy.
Programma di Neurogenetica, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Sci Rep. 2022 Mar 10;12(1):4222. doi: 10.1038/s41598-022-08206-z.
Recent scientific evidence suggests a link between migraine and brain energy metabolism. In fact, migraine is frequently observed in mitochondrial disorders. We studied 46 patients affected by mitochondrial disorders, through a headache-focused semi-structured interview, to evaluate the prevalence of migraine among patients affected by mitochondrial disorders, the possible correlations between migraine and neuromuscular genotype or phenotype, comorbidities, lactate acid levels and brain magnetic resonance spectroscopy. We explored migraine-related disability, analgesic and prophylactic treatments. Diagnoses were achieved according to International Classification of Headache Disorders, 3rd edition. Lifetime prevalence of migraine was 61% (28/46), with high values in both sexes (68% in females, 52% in males) and higher than the values found in both the general population and previous literature. A maternal inheritance pattern was reported in 57% of cases. MIDAS and HIT6 scores revealed a mild migraine-related disability. The high prevalence of migraine across different neuromuscular phenotypes and genotypes suggests that migraine itself may be a common clinical manifestation of brain energy dysfunction. Our results provide new relevant indications in favour of migraine as the result of brain energy unbalance.
最近的科学证据表明偏头痛与大脑能量代谢之间存在关联。事实上，偏头痛经常在 线粒体疾病中观察到。我们通过头痛为重点的半结构化访谈研究了 46 名患有线粒体疾病的患者，以评估偏头痛在患有线粒体疾病的患者中的患病率、偏头痛与神经肌肉基因型或表型、合并症、乳酸水平和脑磁共振波谱之间的可能相关性。我们探讨了偏头痛相关的残疾、镇痛和预防治疗。根据国际头痛疾病分类，第 3 版进行了诊断。偏头痛的终生患病率为 61%（28/46），在男女两性中均有较高值（女性为 68%，男性为 52%），高于一般人群和以往文献中的值。报告了 57%的病例具有母系遗传模式。MIDAS 和 HIT6 评分显示偏头痛相关残疾程度较轻。不同神经肌肉表型和基因型中偏头痛的高患病率表明，偏头痛本身可能是大脑能量功能障碍的常见临床表现。我们的结果提供了新的相关证据，支持偏头痛是大脑能量失衡的结果。
